Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | REN | P00797 | 12/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | APP | P05067 | 1/20 | 0.40 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.40 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.40 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.40 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.40 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.40 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.40 |
| ▸ | CCKBR | P32239 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7315462 | 1.00 | REN (0.44) | RENMAPK1POLBMAPTATM | |
| SCHEMBL7317391 | 1.00 | REN (0.44) | RENMAPK1POLBMAPTATM | |
| SCHEMBL7324681 | 0.95 | REN (0.41) | RENPOLBMAPTATMNPSR1 | |
| SCHEMBL7313196 | 0.95 | REN (0.41) | RENPOLBMAPTATMNPSR1 | |
| SCHEMBL7312788 | 0.92 | REN (0.46) | RENMAPK1POLBMAPTATM | |
| SCHEMBL7309930 | 0.89 | REN (0.46) | REN | |
| SCHEMBL7314665 | 0.89 | REN (0.46) | REN | |
| SCHEMBL7314710 | 0.88 | REN (0.43) | RENMAPK1POLBMAPTATM | |
| SCHEMBL7325787 | 0.84 | MAPT (0.42) | POLBMAPTATMNPSR1TDP1 | |
| SCHEMBL10785485 | 0.83 | REN (0.42) | RENPOLBMAPTTDP1APP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0231919-B1 | N-HETEROCYCLIC ALCOHOL RENIN INHIBITORS | E.R. Squibb & Sons, Inc. (US) | 1993-01-20 | — | — | EP | disclosed |
| EP-0231919-A2 | N-Heterocyclic alcohol renin inhibitors | E.R. Squibb & Sons, Inc. (US) | 1987-08-12 | — | — | EP | disclosed |