Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 7/20 | 0.59 |
| ▸ | L3MBTL3 | Q96JM7 | 7/20 | 0.59 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.59 |
| ▸ | POLB | P06746 | 2/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.59 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.55 |
| ▸ | PARP1 | P09874 | 1/20 | 0.55 |
| ▸ | MAPT | P10636 | 1/20 | 0.55 |
| ▸ | TSHR | P16473 | 1/20 | 0.55 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.55 |
| ▸ | RECQL | P46063 | 1/20 | 0.55 |
| ▸ | BLM | P54132 | 1/20 | 0.55 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.55 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.55 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.55 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.50 |
| ▸ | TP53BP1 | Q12888 | 1/20 | 0.49 |
| ▸ | KDM2B | Q8NHM5 | 2/20 | 0.48 |
| ▸ | MBTD1 | Q05BQ5 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Benzamide SCHEMBL11178664 | 0.95 | L3MBTL3 (0.62) | L3MBTL1L3MBTL3KDM4EPOLBALDH1A1 | |
| Benzamide SCHEMBL1846990 | 0.93 | L3MBTL3 (0.60) | L3MBTL1L3MBTL3KDM4EPOLBALDH1A1 | |
| Benzoic Acid SCHEMBL28780998 | 0.79 | L3MBTL3 (0.64) | L3MBTL1L3MBTL3KDM4EPOLBALDH1A1 | |
| Benzamide SCHEMBL10727410 | 0.79 | KDM4E (0.52) | KDM4EPOLBALDH1A1MAPTTSHR | |
| Benzamide SCHEMBL7761457 | 0.77 | PARP1 (0.84) | L3MBTL1POLBALDH1A1CYP3A4PARP1 | |
| Benzamide SCHEMBL2635777 | 0.76 | MAPT (0.67) | L3MBTL1POLBALDH1A1CYP3A4PARP1 | |
| SCHEMBL8218040 | 0.76 | HRH3 (0.60) | L3MBTL1L3MBTL3PARP1HRH3TP53BP1 | |
| Benzamide SCHEMBL28037993 | 0.75 | PARP1 (0.73) | L3MBTL1POLBALDH1A1CYP3A4PARP1 | |
| Benzamide SCHEMBL2294025 | 0.75 | POLB (0.59) | L3MBTL1POLBCYP3A4PARP1MAPT | |
| SCHEMBL10293557 | 0.75 | L3MBTL3 (1.00) | L3MBTL1L3MBTL3KDM4EPOLBALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0417746-B1 | N-Azabicyclo/3.3.0/octane amides of aromatic acids | SEARLE & CO (US) | 1994-11-23 | — | — | EP | disclosed |
| US-5126343-A | Antiserotonine agents; gastrointestinal disorders | G. D. SEARLE & CO. (US) | 1992-06-30 | — | — | US | disclosed |
| EP-0417746-A2 | N-Azabicyclo/3.3.0/octane amides of aromatic acids | G.D. Searle & Co. (US) | 1991-03-20 | — | — | EP | disclosed |
| US-4992461-A | Treating gastrointestinal disorders | G. D. SEARLE & CO. (US) | 1991-02-12 | — | — | US | disclosed |