Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ERBB2 | P04626 | 3/20 | 0.69 |
| ▸ | EGFR | P00533 | 2/20 | 0.69 |
| ▸ | IGF1R | P08069 | 1/20 | 0.69 |
| ▸ | MEN1 | O00255 | 1/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.56 |
| ▸ | RAF1 | P04049 | 4/20 | 0.55 |
| ▸ | AURKA | O14965 | 1/20 | 0.55 |
| ▸ | TLK2 | Q86UE8 | 3/20 | 0.55 |
| ▸ | JAK3 | P52333 | 2/20 | 0.55 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.55 |
| ▸ | CTRC | Q99895 | 1/20 | 0.55 |
| ▸ | PIM1 | P11309 | 1/20 | 0.51 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.50 |
| ▸ | PDGFRB | P09619 | 3/20 | 0.49 |
| ▸ | FGFR1 | P11362 | 3/20 | 0.49 |
| ▸ | KDR | P35968 | 3/20 | 0.49 |
| ▸ | SRC | P12931 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7316687 | 1.00 | ERBB2 (0.69) | ERBB2EGFRIGF1RMEN1KMT2A | |
| SCHEMBL7702506 | 0.85 | ERBB2 (0.61) | ERBB2EGFRIGF1RRAF1AURKA | |
| SCHEMBL7702511 | 0.85 | ERBB2 (0.61) | ERBB2EGFRIGF1RRAF1AURKA | |
| SCHEMBL7319107 | 0.84 | ERBB2 (0.73) | ERBB2EGFRIGF1RMEN1KMT2A | |
| SCHEMBL7319104 | 0.84 | ERBB2 (0.73) | ERBB2EGFRIGF1RMEN1KMT2A | |
| SCHEMBL5468784 | 0.83 | LRRK2 (0.72) | ERBB2EGFRIGF1RCTRCLRRK2 | |
| SCHEMBL5468785 | 0.83 | LRRK2 (0.72) | ERBB2EGFRIGF1RCTRCLRRK2 | |
| SCHEMBL6694978 | 0.83 | ERBB2 (0.72) | ERBB2EGFRIGF1RMEN1KMT2A | |
| SCHEMBL5773177 | 0.82 | RAF1 (0.79) | EGFRMEN1KMT2ARAF1AURKA | |
| SCHEMBL7982366 | 0.82 | RAF1 (0.69) | ERBB2EGFRMEN1KMT2ARAF1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5124347-A | Inhibits 5-lipoxygenase and cyclooxygenase; for treatment of allergies, arthritis, pain | WARNER-LAMBERT CO. (US) | 1992-06-23 | — | — | US | claimed |
| US-6420428-B1 | TREATING HEPATITIS C AND HEPATIC FIBROSIS USING 2,6-DI-TERT-BUTYLPHENOL DERIVATIVES; EFFECTIVE IN SUBJECTS WITH INTERFERON INSUSCEPTIBILITY | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA | 2002-07-16 | — | — | US | disclosed |
| US-6369097-B1 | Treatment and prevention of hepatic disorders | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA | 2002-04-09 | — | — | US | disclosed |
| US-6348493-B1 | TREATMENT OF HEPATITIS C BY ADMINISTERING 2,6-DI-TER-BUTYLPHENOL | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA | 2002-02-19 | — | — | US | disclosed |
| US-6218437-B1 | ADMINISTERING A THERAPEUTIC AMOUNT OF DI-TERT-BUTYLPHENOL DERIVATIVE TO SUBJECT UNDER CONDITIONS SUCH THAT SAID SYMPTOMS ARE DIMINISHED | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA | 2001-04-17 | — | — | US | disclosed |
| WO-2001021166-A1 | TREATMENT AND PREVENTION OF HEPATIC DISORDERS | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2001-03-29 | — | — | WO | disclosed |
| US-5124347-A | Inhibits 5-lipoxygenase and cyclooxygenase; for treatment of allergies, arthritis, pain | WARNER-LAMBERT CO. (US) | 1992-06-23 | — | — | US | disclosed |