Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Oxalic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BCHE | P06276 | 10/20 | 0.66 |
| ▸ | CARM1 | Q86X55 | 2/20 | 0.60 |
| ▸ | PRMT6 | Q96LA8 | 2/20 | 0.60 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.60 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.60 |
| ▸ | PRMT8 | Q9NR22 | 1/20 | 0.60 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.60 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.55 |
| ▸ | LMNA | P02545 | 1/20 | 0.55 |
| ▸ | CHRM3 | P20309 | 4/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.52 |
| ▸ | TSHR | P16473 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Oxalic Acid SCHEMBL7322850 | 0.89 | BCHE (0.62) | BCHECARM1PRMT6TMEM97SIGMAR1 | |
| SCHEMBL22857053 | 0.84 | CARM1 (0.72) | BCHECARM1PRMT6TMEM97SIGMAR1 | |
| SCHEMBL4030124 | 0.83 | BCHE (0.66) | BCHECARM1PRMT6TMEM97SIGMAR1 | |
| SCHEMBL4024133 | 0.82 | BCHE (0.62) | BCHECARM1PRMT6TMEM97SIGMAR1 | |
| SCHEMBL31705842 | 0.81 | CARM1 (0.64) | BCHECARM1PRMT6TMEM97SIGMAR1 | |
| SCHEMBL7327185 | 0.81 | CARM1 (0.68) | BCHECARM1PRMT6TMEM97SIGMAR1 | |
| SCHEMBL4028855 | 0.80 | BCHE (1.00) | BCHECARM1PRMT6TMEM97SIGMAR1 | |
| SCHEMBL4021849 | 0.80 | BCHE (0.65) | BCHECARM1PRMT6TMEM97SIGMAR1 | |
| SCHEMBL5852484 | 0.79 | KCNH2 (0.64) | BCHEKCNH2KDM4EALDH1A1MEN1 | |
| SCHEMBL8646865 | 0.79 | CARM1 (0.64) | BCHECARM1PRMT6TMEM97SIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0542846-A1 | N-HYDROCARBYL-4-SUBSTITUTED PIPERIDINES, THEIR PREPARATION AND USE AS CALCIUM BLOCKING AGENTS | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1993-05-26 | — | — | EP | disclosed |
| CN-1061963-A | Be used as the croak pyridine class of the 4-replacement of medicine | SMITH KLINE FRENCH LAB (GB) | 1992-06-17 | — | — | CN | disclosed |
| WO-1992002502-A1 | N-HYDROCARBYL-4-SUBSTITUTED PIPERIDINES, THEIR PREPARATION AND USE AS CALCIUM BLOCKING AGENTS | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1992-02-20 | — | — | WO | disclosed |