Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 6/20 | 0.46 |
| ▸ | HTR3A | P46098 | 5/20 | 0.46 |
| ▸ | HTR3E | A5X5Y0 | 4/20 | 0.46 |
| ▸ | HTR3B | O95264 | 4/20 | 0.46 |
| ▸ | HTR3D | Q70Z44 | 4/20 | 0.46 |
| ▸ | HTR3C | Q8WXA8 | 4/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | HTR1D | P28221 | 2/20 | 0.46 |
| ▸ | HTR2C | P28335 | 1/20 | 0.46 |
| ▸ | ADRB1 | P08588 | 3/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | THRB | P10828 | 1/20 | 0.45 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.42 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.42 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.42 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.42 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.42 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28026925 | 0.85 | SIGMAR1 (0.39) | SIGMAR1HTR3AHTR3EHTR3BHTR3D | |
| SCHEMBL9202300 | 0.80 | CHRM2 (0.46) | SIGMAR1HTR3AHTR3EHTR3BHTR3D | |
| SCHEMBL569963 | 0.79 | SIGMAR1 (0.48) | SIGMAR1HTR3AHTR3EHTR3BHTR3D | |
| SCHEMBL12469656 | 0.79 | CYP2B6 (0.59) | SIGMAR1ALDH1A1CHRM2CHRM4CHRM5 | |
| SCHEMBL16672397 | 0.78 | SIGMAR1 (0.41) | SIGMAR1HTR3AHTR3EHTR3BHTR3D | |
| SCHEMBL8411629 | 0.78 | SIGMAR1 (0.47) | SIGMAR1HTR3AHTR3EHTR3BHTR3D | |
| SCHEMBL9090858 | 0.78 | SIGMAR1 (0.47) | SIGMAR1HTR3AHTR3EHTR3BHTR3D | |
| SCHEMBL16052072 | 0.77 | SIGMAR1 (0.41) | SIGMAR1HTR3AHTR3EHTR3BHTR3D | |
| SCHEMBL9530943 | 0.76 | SIGMAR1 (0.46) | SIGMAR1HTR3AHTR3EHTR3BHTR3D | |
| SCHEMBL11114653 | 0.76 | SIGMAR1 (0.45) | SIGMAR1HTR3AHTR3EHTR3BHTR3D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0159566-A1 | Novel piperazine derivatives, processes for production thereof, and pharmaceutical compositions comprising said compounds as active ingredient | KANEBO, LTD. (JP) | 1985-10-30 | — | — | EP | claimed |
| US-4663325-A | 1-(2,3,4-tri-methoxybenzyl)-4[bis(4-fluorophenyl)methyl] piperazines are useful for treating cerebrovascular disease | KANEBO LTD. (JP) | 1987-05-05 | — | — | US | disclosed |
| US-4663325-A | 1-(2,3,4-tri-methoxybenzyl)-4[bis(4-fluorophenyl)methyl] piperazines are useful for treating cerebrovascular disease | KANEBO LTD. (JP) | 1987-05-05 | — | — | US | disclosed |
| EP-0159566-A1 | Novel piperazine derivatives, processes for production thereof, and pharmaceutical compositions comprising said compounds as active ingredient | KANEBO, LTD. (JP) | 1985-10-30 | — | — | EP | disclosed |
| EP-0159566-A1 | Novel piperazine derivatives, processes for production thereof, and pharmaceutical compositions comprising said compounds as active ingredient | KANEBO, LTD. (JP) | 1985-10-30 | — | — | EP | disclosed |