SCHEMBL7317360

SCHEMBL7317360

N#CCc1cccc(OC[C@H]2CCCN2C(=O)O)c1

nearest known ligand 0.49

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
SPHK2 Q9NRA0 3/20 0.47
CHRNB4 P30926 4/20 0.46
CHRNA3 P32297 4/20 0.46
CHRNB2 P17787 2/20 0.46
CHRNA4 P43681 1/20 0.46
FAAH O00519 2/20 0.44
CHRNB1 P11230 1/20 0.42
CHRNB3 Q05901 1/20 0.42
JAK2 O60674 1/20 0.42
DPP4 P27487 1/20 0.41
SPHK1 Q9NYA1 1/20 0.41
HCRTR1 O43613 1/20 0.41
HCRTR2 O43614 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20658821 0.86 SPHK2 (0.53) SPHK2CHRNB4CHRNA3CHRNB2CHRNA4
SCHEMBL7310489 0.83 SPHK2 (0.47) SPHK2CHRNB4CHRNA3CHRNB2CHRNA4
SCHEMBL3827589 0.83 SPHK2 (0.66) SPHK2CHRNB4CHRNA3CHRNB2CHRNA4
SCHEMBL15811746 0.80 ABHD6 (0.54) CHRNB4CHRNA3CHRNB2CHRNA4DPP4
SCHEMBL4140738 0.80 ABHD6 (0.54) CHRNB4CHRNA3CHRNB2CHRNA4DPP4
SCHEMBL3163185 0.80 FFAR1 (0.55) CHRNB4CHRNA3CHRNB2CHRNA4
SCHEMBL2260961 0.80 CHRNB4 (0.50) SPHK2CHRNB4CHRNA3CHRNB2CHRNA4
SCHEMBL21521839 0.79 CHRNB4 (0.50) SPHK2CHRNB4CHRNA3CHRNB2CHRNA4
SCHEMBL5318408 0.78 CHRNB4 (0.53) SPHK2CHRNB4CHRNA3CHRNB2CHRNA4
SCHEMBL5413716 0.77 FFAR1 (0.55) CHRNB2CHRNA4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6417203-B1 HETEROCYCLIC AMIDES PFIZER INC. 2002-07-09 US disclosed
US-6180627-B1 INDOLE, INDAZOLE, BENZOTRIAZOLE AND BENZIMIDAZOLE DERIVATIVES PFIZER INC. 2001-01-30 US disclosed
EP-0997474-A1 Antithrombotic agents PFIZER INC. (US) 2000-05-03 EP disclosed