Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | OPRK1 | P41145 | 3/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.36 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 2/20 | 0.36 |
| ▸ | RECQL | P46063 | 1/20 | 0.36 |
| ▸ | SERPINH1 | P50454 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | ABL1 | P00519 | 1/20 | 0.35 |
| ▸ | PTGDR | Q13258 | 1/20 | 0.34 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7318335 | 1.00 | KDM4E (0.39) | KDM4EHSD17B10ALDH1A1HPGDNPSR1 | |
| SCHEMBL7311217 | 1.00 | KDM4E (0.39) | KDM4EHSD17B10ALDH1A1HPGDNPSR1 | |
| SCHEMBL7317477 | 1.00 | KDM4E (0.39) | KDM4EHSD17B10ALDH1A1HPGDNPSR1 | |
| SCHEMBL8323720 | 0.84 | MEN1 (0.32) | MEN1KMT2A | |
| SCHEMBL7395961 | 0.84 | HSD17B10 (0.37) | KDM4EHSD17B10ALDH1A1HPGDTSHR | |
| SCHEMBL7312354 | 0.84 | HSD17B10 (0.37) | KDM4EHSD17B10ALDH1A1HPGDTSHR | |
| SCHEMBL9487213 | 0.84 | HSD17B10 (0.37) | KDM4EHSD17B10ALDH1A1HPGDTSHR | |
| SCHEMBL7311245 | 0.84 | HSD17B10 (0.37) | KDM4EHSD17B10ALDH1A1HPGDTSHR | |
| SCHEMBL7312361 | 0.84 | HSD17B10 (0.37) | KDM4EHSD17B10ALDH1A1HPGDTSHR | |
| Hydrochloric Acid SCHEMBL8323728 | 0.83 | HSD17B10 (0.36) | KDM4EHSD17B10ALDH1A1HPGDTSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5288731-A | Antiemetics, antiserotonine agents | RHONE-POULENC RORER PHARMACEUTICALS INC. (US) | 1994-02-22 | — | — | US | disclosed |
| US-5246942-A | Central nervous system, anti-emetic and gastric prokinetic activity | RHONE-POULENC RORER PHARMACEUTICALS INC. (US) | 1993-09-21 | — | — | US | disclosed |
| EP-0494140-A4 | DIBENZOFURANCARBOXAMIDES | — | 1992-09-02 | — | — | EP | disclosed |
| EP-0494140-A1 | DIBENZOFURANCARBOXAMIDES | RORER INTERNATIONAL (HOLDINGS), INC. (US) | 1992-07-15 | — | — | EP | disclosed |
| WO-1991004738-A1 | DIBENZOFURANCARBOXAMIDES | RORER INTERNATIONAL (HOLDINGS), INC. (US) | 1991-04-18 | — | — | WO | disclosed |
| US-4959485-A | 5-HT3 ANTAGONISTS | RORER PHARMACEUTICAL CORPORATION (US) | 1990-09-25 | — | — | US | disclosed |
| WO-1989010364-A1 | DIBENZOFURANCARBOXAMIDES | RORER INTERNATIONAL (OVERSEAS) INC. (US) | 1989-11-02 | — | — | WO | disclosed |
| EP-0339950-A2 | Dibenzofurancarboxamides, their use as pharmaceutical agents, a composition containing the same, and a process for the preparation thereof | RHONE-POULENC RORER INTERNATIONAL (HOLDINGS) INC. (US) | 1989-11-02 | — | — | EP | disclosed |
| US-4863921-A | Dibenzofurancarboxamides and their pharmaceutical compositions and methods | RORER PHARMACEUTICAL CORPORATION (US) | 1989-09-05 | — | — | US | disclosed |