Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGB3 | P05106 | 1/20 | 0.55 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.55 |
| ▸ | MALT1 | Q9UDY8 | 1/20 | 0.55 |
| ▸ | CMA1 | P23946 | 7/20 | 0.52 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.50 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.50 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.50 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.50 |
| ▸ | KLK7 | P49862 | 2/20 | 0.49 |
| ▸ | KLK5 | Q9Y337 | 2/20 | 0.49 |
| ▸ | DPP4 | P27487 | 1/20 | 0.48 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.48 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.48 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.48 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7312175 | 0.98 | ITGB3 (0.58) | ITGB3ITGA2BMALT1CMA1KLK7 | |
| SCHEMBL7322601 | 0.94 | ITGB3 (0.57) | ITGB3ITGA2BMALT1CMA1KLK7 | |
| SCHEMBL7309936 | 0.93 | ITGB3 (0.59) | ITGB3ITGA2BMALT1CMA1KLK7 | |
| SCHEMBL7320588 | 0.91 | MALT1 (0.59) | ITGB3ITGA2BMALT1DPP4DPP8 | |
| SCHEMBL7316481 | 0.91 | ITGB3 (0.49) | ITGB3ITGA2BMALT1CMA1ADORA3 | |
| SCHEMBL5971737 | 0.89 | ITGB3 (0.66) | ITGB3ITGA2BCMA1ADORA3ADORA2A | |
| SCHEMBL7312472 | 0.88 | ITGB3 (0.59) | ITGB3ITGA2BCMA1ADORA3ADORA2A | |
| SCHEMBL7320222 | 0.88 | CMA1 (0.56) | ITGB3ITGA2BMALT1CMA1KLK7 | |
| SCHEMBL7321341 | 0.88 | CMA1 (0.56) | ITGB3ITGA2BMALT1CMA1KLK7 | |
| SCHEMBL7311270 | 0.87 | MALT1 (0.53) | ITGB3ITGA2BMALT1CMA1DPP4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4691007-A | HUMAN LEUKOCYTE ELASTASE INHIBITORS | ICI AMERICAS INC. (US) | 1987-09-01 | — | — | US | disclosed |
| US-4596789-A | Pharmaceuticals | ICI AMERICAS INC. (US) | 1986-06-24 | — | — | US | disclosed |
| EP-0124317-A2 | Proline derivatives | ICI AMERICAS INC. (US) | 1984-11-07 | — | — | EP | disclosed |