Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 18/20 | 0.48 |
| ▸ | ADORA1 | P30542 | 7/20 | 0.46 |
| ▸ | ADORA2B | P29275 | 5/20 | 0.46 |
| ▸ | ADORA2A | P29274 | 3/20 | 0.46 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7315323 | 0.95 | PDE4B (0.47) | PDE4BADORA1ADORA2BADORA2A | |
| SCHEMBL7314416 | 0.90 | PDE4B (0.43) | PDE4BADORA1ADORA2BADORA2ALMNA | |
| SCHEMBL7306912 | 0.88 | PDE4B (0.48) | PDE4BADORA1ADORA2BADORA2ALMNA | |
| SCHEMBL7306806 | 0.87 | PDE4B (0.62) | PDE4BADORA1ADORA2BADORA2A | |
| SCHEMBL7305094 | 0.86 | PDE4B (0.60) | PDE4BADORA1ADORA2BADORA2A | |
| SCHEMBL7308822 | 0.84 | PDE4B (0.59) | PDE4BADORA1ADORA2BADORA2A | |
| SCHEMBL7308447 | 0.84 | PDE4B (0.59) | PDE4BADORA1ADORA2BADORA2A | |
| SCHEMBL7315409 | 0.84 | PDE4B (0.55) | PDE4BADORA1ADORA2BADORA2A | |
| SCHEMBL7306144 | 0.84 | PDE4B (0.57) | PDE4BADORA1ADORA2BADORA2A | |
| SCHEMBL7316189 | 0.83 | PDE4B (0.57) | PDE4BADORA1ADORA2BADORA2ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2394998-A1 | 3-(5-Amino-6-oxo-1,6-dihydropyridazin-3-yl)-biphenyl derivatives as PDE4 inhibitors | Almirall, S.A. (ES) | 2011-12-14 | — | — | EP | claimed |
| EP-2394998-A1 | 3-(5-Amino-6-oxo-1,6-dihydropyridazin-3-yl)-biphenyl derivatives as PDE4 inhibitors | Almirall, S.A. (ES) | 2011-12-14 | — | — | EP | disclosed |
| EP-2394998-A1 | 3-(5-Amino-6-oxo-1,6-dihydropyridazin-3-yl)-biphenyl derivatives as PDE4 inhibitors | Almirall, S.A. (ES) | 2011-12-14 | — | — | EP | disclosed |