Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | REN | P00797 | 19/20 | 0.66 |
| ▸ | PGC | P20142 | 1/20 | 0.57 |
| ▸ | PGA5 | P0DJD9 | 1/20 | 0.56 |
| ▸ | ACE | P12821 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27673678 | 0.92 | REN (0.65) | RENPGCPGA5 | |
| SCHEMBL27335661 | 0.92 | REN (0.65) | RENPGCPGA5 | |
| SCHEMBL25054176 | 0.91 | REN (0.57) | RENPGCPGA5 | |
| SCHEMBL27608533 | 0.90 | REN (0.56) | RENPGCPGA5 | |
| SCHEMBL1132649 | 0.88 | ITGB2 (0.57) | RENACE | |
| SCHEMBL1133307 | 0.88 | ITGB2 (0.57) | RENACE | |
| SCHEMBL14028689 | 0.88 | ITGB2 (0.57) | RENACE | |
| SCHEMBL28684251 | 0.87 | ITGB2 (0.56) | RENACE | |
| SCHEMBL10825122 | 0.86 | REN (0.73) | REN | |
| SCHEMBL2367371 | 0.86 | ACE (0.72) | RENACE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0231919-B1 | N-HETEROCYCLIC ALCOHOL RENIN INHIBITORS | E.R. Squibb & Sons, Inc. (US) | 1993-01-20 | — | — | EP | disclosed |
| US-4885292-A | HYPOTENSIVE AGENTS | E. R. SQUIBB & SONS, INC. (US) | 1989-12-05 | — | — | US | disclosed |
| US-4757050-A | Urea, amide group-containing | E. R. SQUIBB SONS, INC. (US) | 1988-07-12 | — | — | US | disclosed |
| EP-0231919-A2 | N-Heterocyclic alcohol renin inhibitors | E.R. Squibb & Sons, Inc. (US) | 1987-08-12 | — | — | EP | disclosed |