Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FFAR1 | O14842 | 14/20 | 0.45 |
| ▸ | FFAR4 | Q5NUL3 | 12/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | GPR17 | Q13304 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28632810 | 0.90 | F13A1 (0.43) | FFAR1FFAR4 | |
| SCHEMBL7318302 | 0.84 | MPO (0.37) | FFAR1FFAR4POLB | |
| SCHEMBL10603384 | 0.81 | POLB (0.51) | FFAR1FFAR4NPSR1POLB | |
| SCHEMBL1478187 | 0.81 | FFAR1 (0.51) | FFAR1FFAR4NPSR1POLB | |
| SCHEMBL28982098 | 0.79 | PSEN1 (0.33) | — | |
| SCHEMBL5427170 | 0.79 | FFAR1 (0.49) | FFAR1FFAR4NPSR1POLBGPR17 | |
| SCHEMBL12261416 | 0.79 | FFAR1 (0.55) | FFAR1FFAR4NPSR1POLBGPR17 | |
| SCHEMBL14460289 | 0.79 | NPSR1 (0.63) | FFAR1FFAR4NPSR1POLB | |
| SCHEMBL4872028 | 0.78 | POLB (0.60) | FFAR1FFAR4NPSR1POLB | |
| SCHEMBL30637597 | 0.78 | FFAR1 (0.59) | FFAR1FFAR4NPSR1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4742084-A | Aralykyl (arylethynyl)aralkyl amines and their use as vasodilators and antihypertensives | MCNEILAB, INC. (US) | 1988-05-03 | — | — | US | disclosed |
| EP-0155079-B1 | ACETYLENE AMINES AND THEIR USE AS VASODILATORS AND ANTIHYPERTENSIVES | McNeilab, Inc. (US) | 1988-02-17 | — | — | EP | disclosed |
| US-4725602-A | Acetylene amines and their use as vasodilators and antihypertensives | MCNEILAB, INC. (US) | 1988-02-16 | — | — | US | disclosed |
| US-4661635-A | ANTIARRHYTHMIA AGENTS | MCNEILAB, INC. (US) | 1987-04-28 | — | — | US | disclosed |
| EP-0155079-A1 | Acetylene amines and their use as vasodilators and antihypertensives | McNeilab, Inc. (US) | 1985-09-18 | — | — | EP | disclosed |
| EP-0146271-A2 | Aralykyl (arylethynyl) aralkyl amines for use as vasodilators and antihypertensives | McNeilab, Inc. (US) | 1985-06-26 | — | — | EP | disclosed |