Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP9 | P14780 | 19/20 | 0.63 |
| ▸ | MMP13 | P45452 | 19/20 | 0.63 |
| ▸ | MMP1 | P03956 | 18/20 | 0.63 |
| ▸ | ADAM17 | P78536 | 16/20 | 0.63 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.61 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7314648 | 0.92 | MMP9 (0.75) | MMP9MMP13MMP1ADAM17KEAP1 | |
| SCHEMBL27511006 | 0.91 | MMP9 (0.75) | MMP9MMP13MMP1ADAM17 | |
| SCHEMBL7322105 | 0.88 | MMP9 (0.69) | MMP9MMP13MMP1ADAM17KEAP1 | |
| SCHEMBL7311162 | 0.87 | MMP9 (0.81) | MMP9MMP13MMP1ADAM17 | |
| SCHEMBL7451383 | 0.86 | MMP9 (0.83) | MMP9MMP13MMP1ADAM17 | |
| SCHEMBL7449515 | 0.85 | MMP9 (0.86) | MMP9MMP13MMP1ADAM17 | |
| SCHEMBL7504340 | 0.83 | MMP9 (0.70) | MMP9MMP13MMP1ADAM17 | |
| SCHEMBL7448977 | 0.83 | MMP9 (0.64) | MMP9MMP13MMP1ADAM17KEAP1 | |
| SCHEMBL7317808 | 0.82 | MMP9 (0.81) | MMP9MMP13MMP1ADAM17 | |
| SCHEMBL7314677 | 0.81 | MMP9 (0.72) | MMP9MMP13MMP1ADAM17KEAP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0938471-B1 | THE PREPARATION AND USE OF ORTHO-SULFONAMIDO ARYL HYDROXAMIC ACIDS AS MATRIX METALLOPROTEINASE AND TACE INHIBITORS | AMERICAN CYANAMID CO (US) | 2001-12-12 | — | — | EP | disclosed |
| US-5929097-A | INHIBIT TUMOR NECROSIS FACTOR-ALPHA CONVERTING ENZYME | AMERICAN CYANAMID COMPANY (US) | 1999-07-27 | — | — | US | disclosed |