Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 11/20 | 0.50 |
| ▸ | PDE4B | Q07343 | 10/20 | 0.50 |
| ▸ | PDE4C | Q08493 | 8/20 | 0.50 |
| ▸ | PDE4D | Q08499 | 8/20 | 0.50 |
| ▸ | CTSS | P25774 | 1/20 | 0.46 |
| ▸ | CTSK | P43235 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | PDE5A | O76074 | 1/20 | 0.45 |
| ▸ | PDE1A | P54750 | 1/20 | 0.45 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.45 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7326043 | 0.82 | PDE4B (0.49) | PDE4APDE4BPDE4CPDE4DPOLB | |
| SCHEMBL7358687 | 0.79 | POLB (0.51) | PDE4APDE4BPDE4CPDE4DCTSK | |
| SCHEMBL30530004 | 0.79 | PDE4B (0.60) | PDE4APDE4BPDE4CPDE4DPOLB | |
| SCHEMBL7363289 | 0.79 | PDE4B (0.60) | PDE4APDE4BPDE4CPDE4DPOLB | |
| SCHEMBL29061976 | 0.79 | PDE4A (0.56) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL29061973 | 0.79 | PDE4A (0.56) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL7323055 | 0.78 | EPHX1 (0.44) | PDE4APDE4BPDE4CPDE4DCTSS | |
| SCHEMBL8570355 | 0.77 | PDE4A (0.49) | PDE4APDE4BPDE4CPDE4DPOLB | |
| SCHEMBL8573504 | 0.77 | PDE4A (0.58) | PDE4APDE4BPDE4CPDE4DCTSK | |
| Acetic Acid SCHEMBL2459347 | 0.76 | PDE4A (0.52) | PDE4APDE4BPDE4CPDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0557408-A4 | IMIDAZOLIDINONE COMPOUNDS | — | 1993-10-27 | — | — | EP | disclosed |
| EP-0557408-A1 | IMIDAZOLIDINONE COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 1993-09-01 | — | — | EP | disclosed |
| WO-1992007567-A1 | IMIDAZOLIDINONE COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 1992-05-14 | — | — | WO | disclosed |