Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.55 |
| ▸ | GAA | P10253 | 1/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.55 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.55 |
| ▸ | ADRB2 | P07550 | 12/20 | 0.54 |
| ▸ | ADRB1 | P08588 | 6/20 | 0.54 |
| ▸ | DRD2 | P14416 | 2/20 | 0.54 |
| ▸ | DRD1 | P21728 | 2/20 | 0.54 |
| ▸ | DRD4 | P21917 | 2/20 | 0.54 |
| ▸ | DRD3 | P35462 | 2/20 | 0.54 |
| ▸ | ADRB3 | P13945 | 6/20 | 0.53 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.45 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9239987 | 1.00 | KDM4E (0.55) | KDM4EGAASMN1; SMN2TDP1ADRB2 | |
| SCHEMBL7301591 | 1.00 | KDM4E (0.55) | KDM4EGAASMN1; SMN2TDP1ADRB2 | |
| Oxalic Acid SCHEMBL9239982 | 0.87 | KDM4E (0.64) | KDM4EGAASMN1; SMN2TDP1ADRB2 | |
| Oxalic Acid SCHEMBL7318481 | 0.87 | KDM4E (0.64) | KDM4EGAASMN1; SMN2TDP1ADRB2 | |
| SCHEMBL7291429 | 0.80 | ADRB2 (0.47) | KDM4EADRB2ADRB1DRD2DRD1 | |
| SCHEMBL9239995 | 0.78 | IGF1R (0.48) | KDM4EGAASMN1; SMN2TDP1ADRB2 | |
| SCHEMBL9677594 | 0.78 | IGF1R (0.48) | KDM4EGAASMN1; SMN2TDP1ADRB2 | |
| SCHEMBL15277792 | 0.77 | ADRB2 (0.69) | ADRB2ADRB1DRD2DRD3ADRB3 | |
| SCHEMBL11023341 | 0.75 | ADRB2 (0.57) | KDM4EADRB2ADRB1DRD2DRD1 | |
| SCHEMBL674690 | 0.72 | KDM4E (0.54) | KDM4EGAASMN1; SMN2TDP1ADRB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0658538-B1 | Diagnosis, evaluation and treatment of coronary artery disease by exercise simulation using closed loop drug delivery of an exercise simulating agent beta agonist | GENSIA INC (US) | 1997-10-29 | — | — | EP | disclosed |
| EP-0329464-B1 | System for the closed-loop administration of an exercise simulating agent | GENSIA INC (US) | 1995-11-02 | — | — | EP | disclosed |
| US-5460605-A | Diagnosis, evaluation and treatment of coronary artery disease by exercise simulation using closed loop drug delivery of an exercise simulating agent beta agonist | GENSIA, INC. (US) | 1995-10-24 | — | — | US | disclosed |
| EP-0658538-A1 | Diagnosis, evaluation and treatment of coronary artery disease by exercise simulation using closed loop drug delivery of an exercise simulating agent beta agonist | GENSIA, INC. (US) | 1995-06-21 | — | — | EP | disclosed |
| US-5395970-A | 1-(3,4-dihydroxyphenyl)-2-(4-(4-hydroxyphenyl)butaylamino)ethanol | GENSIA PHARMACEUTICALS, INC. (US) | 1995-03-07 | — | — | US | disclosed |
| US-5286252-A | Diagnosis, evaluation and treatment of coronary artery disease by exercise simulation using closed loop drug delivery of an exercise simulating agent beta agonist | GENSIA PHARMACEUTICALS, INC. (US) | 1994-02-15 | — | — | US | disclosed |
| US-5234404-A | Diagnosis, evaluation and treatment of coronary artery disease by exercise simulation using closed loop drug delivery of an exercise simulating agent beta agonist | GENSIA PHARMACEUTICALS, INC. (US) | 1993-08-10 | — | — | US | disclosed |
| US-5108363-A | DIAGNOSIS, EVALUATION AND TREATMENT OF CORONARY ARTERY DISEASE BY EXERCISE SIMULATION USING CLOSED LOOP DRUG DELIVERY OF AN EXERCISE SIMULATING AGENT BETA AGONIST | GENSIA PHARMACEUTICALS, INC. (US) | 1992-04-28 | — | — | US | disclosed |