Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AR | P10275 | 8/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.40 |
| ▸ | PGR | P06401 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.40 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | SLC9A1 | P19634 | 3/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | CES2 | O00748 | 1/20 | 0.38 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | GLA | P06280 | 1/20 | 0.38 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.38 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL7323889 | 0.99 | AR (0.40) | ARCYP3A4PGRALDH1A1MAPT | |
| SCHEMBL10550294 | 0.80 | KDM4E (0.41) | ALDH1A1MEN1KMT2AKDM4ESLC9A1 | |
| Hydrochloric Acid SCHEMBL7325678 | 0.79 | KDM4E (0.40) | ALDH1A1MEN1KMT2AKDM4ESLC9A1 | |
| Hydrochloric Acid SCHEMBL7322286 | 0.79 | KDM4E (0.40) | ALDH1A1MEN1KMT2AKDM4ESLC9A1 | |
| SCHEMBL7318500 | 0.79 | KDM4E (0.42) | ARCYP3A4PGRALDH1A1MAPT | |
| Hydrochloric Acid SCHEMBL7323883 | 0.78 | KDM4E (0.41) | ARCYP3A4PGRALDH1A1MAPT | |
| Hydrochloric Acid SCHEMBL7318923 | 0.76 | PDE4A (0.46) | ALDH1A1KDM4ESLC9A1KCNH2 | |
| SCHEMBL11781836 | 0.76 | MAPT (0.57) | ALDH1A1MAPTMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL11711488 | 0.76 | AR (0.48) | ARCYP3A4PGRALDH1A1MAPT | |
| Hydrochloric Acid SCHEMBL11779824 | 0.75 | MAPT (0.56) | ALDH1A1MAPTMEN1KMT2ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4882354-A | N-hydroxy-5-phenyl-2-furancarboximidamides useful as cardiotonic agents | NORWICH EATON PHARMACEUTICALS, INC. (US) | 1989-11-21 | — | — | US | disclosed |
| EP-0321431-A1 | N-hydroxy-5-phenyl-2-furancarboximidamides useful as cardiotonic agents | Norwich Eaton Pharmaceuticals, Inc. (US) | 1989-06-21 | — | — | EP | disclosed |