Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP3K7 | O43318 | 1/20 | 0.39 |
| ▸ | TAB1 | Q15750 | 1/20 | 0.39 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.37 |
| ▸ | CCNC | P24863 | 1/20 | 0.33 |
| ▸ | CDK8 | P49336 | 1/20 | 0.33 |
| ▸ | IP6K1 | Q92551 | 1/20 | 0.31 |
| ▸ | IP6K2 | Q9UHH9 | 1/20 | 0.31 |
| ▸ | JAK3 | P52333 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10540316 | 1.00 | MAP3K7 (0.39) | MAP3K7TAB1NR4A2CCNCCDK8 | |
| SCHEMBL6181311 | 0.81 | KDM4E (0.41) | MAP3K7TAB1 | |
| SCHEMBL1902161 | 0.81 | KDM4E (0.41) | MAP3K7TAB1 | |
| SCHEMBL6718396 | 0.79 | KDM4E (0.40) | MAP3K7TAB1 | |
| SCHEMBL9032838 | 0.77 | KMT2A (0.47) | MAP3K7TAB1 | |
| SCHEMBL6181182 | 0.74 | CA12 (0.46) | CCNCCDK8 | |
| SCHEMBL6726458 | 0.74 | CA12 (0.46) | CCNCCDK8 | |
| SCHEMBL7322217 | 0.71 | MAP3K7 (0.37) | MAP3K7TAB1NR4A2CCNCCDK8 | |
| SCHEMBL3003194 | 0.71 | MAP3K7 (0.37) | MAP3K7TAB1NR4A2CCNCCDK8 | |
| SCHEMBL5345993 | 0.70 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0242973-B1 | INDOLE DERIVATIVES, METHOD FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | GLAXO GROUP LIMITED (GB) | 1991-07-17 | — | — | EP | disclosed |
| US-4808581-A | ANXIOLYTIC, ANTIEMETIC, TREATMENT OF PSYCHOLOGICAL DISORDERS | GLAXO GROUP LIMITED (GB) | 1989-02-28 | — | — | US | disclosed |
| EP-0242973-A1 | Indole derivatives, method for their preparation and pharmaceutical compositions containing them | GLAXO GROUP LIMITED (GB) | 1987-10-28 | — | — | EP | disclosed |