Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IKBKB | O14920 | 6/20 | 0.43 |
| ▸ | FLT3 | P36888 | 1/20 | 0.35 |
| ▸ | AURKA | O14965 | 1/20 | 0.34 |
| ▸ | CHUK | O15111 | 3/20 | 0.33 |
| ▸ | TTK | P33981 | 1/20 | 0.33 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.33 |
| ▸ | YTHDC1 | Q96MU7 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31285537 | 0.85 | IKBKB (0.46) | IKBKBFLT3AURKACHUKYTHDC1 | |
| SCHEMBL14432369 | 0.85 | IKBKB (0.41) | IKBKBFLT3AURKACHUKTTK | |
| SCHEMBL19748170 | 0.83 | IKBKB (0.36) | IKBKBFLT3CHUKTTKLRRK2 | |
| SCHEMBL7324280 | 0.82 | TTK (0.38) | IKBKBAURKACHUKTTKLRRK2 | |
| SCHEMBL29856433 | 0.80 | TTK (0.35) | IKBKBFLT3CHUKTTKLRRK2 | |
| SCHEMBL25394938 | 0.79 | TTK (0.36) | IKBKBFLT3CHUKTTKYTHDC1 | |
| SCHEMBL31285713 | 0.79 | IKBKB (0.39) | IKBKBFLT3AURKACHUKYTHDC1 | |
| SCHEMBL31285456 | 0.77 | IKBKB (0.38) | IKBKBFLT3AURKACHUKTTK | |
| SCHEMBL2179685 | 0.76 | AURKA (0.30) | AURKA | |
| SCHEMBL14507645 | 0.74 | LCK (0.54) | AURKA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5028605-A | Antispasmodic, bronchodilators, uterine relaxants, cardiac analeptics, neurosedatives | L'UNIVERSITE DE MONTPELLIER I (FR) | 1991-07-02 | — | — | US | disclosed |
| EP-0348392-A1 | 8-ALKYLAMINOIMIDAZO[1,2-A]PYRAZINES AND DERIVATIVES, THEIR PREPARATION AND THEIR APPLICATION IN THERAPY | Université Montpellier I (FR) | 1990-01-03 | — | — | EP | disclosed |
| WO-1988004298-A1 | 8-ALKYLAMINOIMIDAZO[1,2-A]PYRAZINES AND DERIVATIVES, THEIR PREPARATION AND THEIR APPLICATION IN THERAPY | BYK GULDEN LOMBERG CHEMISCHE FABRIK GMBH (DE) | 1988-06-16 | — | — | WO | disclosed |