Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MALT1 | Q9UDY8 | 1/20 | 0.51 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.48 |
| ▸ | FAP | Q12884 | 1/20 | 0.48 |
| ▸ | DPP4 | P27487 | 1/20 | 0.47 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.47 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.47 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.47 |
| ▸ | CTSD | P07339 | 2/20 | 0.46 |
| ▸ | CTSE | P14091 | 2/20 | 0.46 |
| ▸ | BACE1 | P56817 | 2/20 | 0.46 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.45 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.45 |
| ▸ | ACE | P12821 | 2/20 | 0.45 |
| ▸ | CMA1 | P23946 | 3/20 | 0.44 |
| ▸ | REN | P00797 | 1/20 | 0.44 |
| ▸ | PRCP | P42785 | 1/20 | 0.44 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7314536 | 0.96 | MALT1 (0.51) | MALT1PSMB5FAPDPP4DPP8 | |
| SCHEMBL7320588 | 0.90 | MALT1 (0.59) | MALT1PSMB5DPP4DPP8DPP9 | |
| SCHEMBL7316605 | 0.90 | MALT1 (0.50) | MALT1PSMB5FAPDPP4DPP8 | |
| SCHEMBL7318250 | 0.89 | MALT1 (0.51) | MALT1PSMB5FAPDPP4DPP8 | |
| SCHEMBL7321788 | 0.87 | ACE (0.52) | FAPDPP4DPP8DPP9DPP7 | |
| SCHEMBL7311270 | 0.87 | MALT1 (0.53) | MALT1PSMB5DPP4DPP8DPP9 | |
| SCHEMBL7309936 | 0.86 | ITGB3 (0.59) | MALT1ITGB3ITGA2BACECMA1 | |
| SCHEMBL7320410 | 0.86 | MALT1 (0.53) | MALT1PSMB5FAPDPP4DPP8 | |
| SCHEMBL7312528 | 0.86 | MALT1 (0.51) | MALT1PSMB5FAPDPP4DPP8 | |
| SCHEMBL7322601 | 0.82 | ITGB3 (0.57) | MALT1ITGB3ITGA2BCMA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4691007-A | HUMAN LEUKOCYTE ELASTASE INHIBITORS | ICI AMERICAS INC. (US) | 1987-09-01 | — | — | US | disclosed |
| US-4596789-A | Pharmaceuticals | ICI AMERICAS INC. (US) | 1986-06-24 | — | — | US | disclosed |
| EP-0124317-A2 | Proline derivatives | ICI AMERICAS INC. (US) | 1984-11-07 | — | — | EP | disclosed |