Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 2/20 | 0.51 |
| ▸ | MME | P08473 | 13/20 | 0.50 |
| ▸ | ACE | P12821 | 7/20 | 0.50 |
| ▸ | PPARA | Q07869 | 2/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.50 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.50 |
| ▸ | ABCC3 | O15438 | 1/20 | 0.50 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.50 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.50 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.50 |
| ▸ | RARG | P13631 | 1/20 | 0.50 |
| ▸ | CNR1 | P21554 | 1/20 | 0.50 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.50 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.50 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.50 |
| ▸ | NR1I3 | Q14994 | 1/20 | 0.50 |
| ▸ | SRR | Q9GZT4 | 1/20 | 0.48 |
| ▸ | PSAT1 | Q9Y617 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8861587 | 1.00 | CYP1A2 (0.51) | CYP1A2MMEACEPPARACYP3A4 | |
| SCHEMBL838962 | 0.91 | CYP1A2 (0.63) | CYP1A2MMEPPARACYP3A4CYP2D6 | |
| SCHEMBL838961 | 0.91 | CYP1A2 (0.63) | CYP1A2MMEPPARACYP3A4CYP2D6 | |
| SCHEMBL6154521 | 0.91 | CYP1A2 (0.63) | CYP1A2MMEPPARACYP3A4CYP2D6 | |
| Hydrochloric Acid SCHEMBL6572923 | 0.89 | CYP1A2 (0.61) | CYP1A2MMEPPARACYP3A4CYP2D6 | |
| Hydrochloric Acid SCHEMBL6572922 | 0.89 | CYP1A2 (0.61) | CYP1A2MMEPPARACYP3A4CYP2D6 | |
| SCHEMBL7319197 | 0.88 | PPARA (0.48) | CYP1A2MMEACEPPARACYP3A4 | |
| Benzoquinone SCHEMBL28513425 | 0.85 | CYP1A2 (0.56) | CYP1A2MMEPPARACYP3A4CYP2D6 | |
| SCHEMBL7435690 | 0.84 | CYP1A2 (0.46) | CYP1A2PPARACYP3A4CYP2D6CYP2C9 | |
| SCHEMBL6169549 | 0.84 | MME (0.60) | MMEACE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110194731-B | Mercaptopropionic acid amide compound, preparation method and medicinal application thereof | 复旦大学 | 2021-05-04 | — | — | CN | disclosed |
| US-5846956-A | Amino acids derivatives, the process for their preparation and their applications to therapy | SOCIETE CIVILE BIOPROJET (FR) | 1998-12-08 | — | — | US | disclosed |
| US-5670531-A | ENKEPHALINASE OR ANGIOTENSIN CONVERTING ENZYME INHIBITORS | SOCIETE CIVILE BIOPROJET (FR) | 1997-09-23 | — | — | US | disclosed |
| US-5644055-A | Antihypertensive tricyclic azepine derivatives useful as inhibitors of enkephalinase and ACE | CIBA-GEIGY CORPORATION (US) | 1997-07-01 | — | — | US | disclosed |
| US-5599951-A | ENZYME INHIBITORS | SOCIETE CIVILE BIOPROJET (FR) | 1997-02-04 | — | — | US | disclosed |
| EP-0706525-A1 | ANTIHYPERTENSIVE TRICYCLIC AZEPINE DERIVATIVES USEFUL AS INHIBITORS OF ENKEPHALINASE AND ACE | Novartis AG (CH) | 1996-04-17 | — | — | EP | disclosed |
| WO-1995001353-A1 | ANTIHYPERTENSIVE TRICYCLIC AZEPINE DERIVATIVES USEFUL AS INHIBITORS OF ENKEPHALINASE AND ACE | CIBA-GEIGY AG (CH) | 1995-01-12 | — | — | WO | disclosed |
| US-5262436-A | Administering; enzyme inhibitor | SCHERING CORPORATION (US) | 1993-11-16 | — | — | US | disclosed |
| EP-0566157-A1 | Neutral metalloendopeptidase inhibitors in the treatment of hypertension | SCHERING CORPORATION (US) | 1993-10-20 | — | — | EP | disclosed |
| US-5061710-A | Atrial natriuretic factors | SCHERING CORPORATION (US) | 1991-10-29 | — | — | US | disclosed |
| US-4929641-A | DIURETICS, ANGIOTENSIN CONVERTING ENZYMES | SCHERING CORPORATION (US) | 1990-05-29 | — | — | US | disclosed |
| US-4801609-A | Mercapto-acylamino acid antihypertensives | SCHERING CORPORATION (US) | 1989-01-31 | — | — | US | disclosed |
| EP-0254032-A2 | Neutral metalloendopeptidase inhibitors in the treatment of hypertension | SCHERING CORPORATION (US) | 1988-01-27 | — | — | EP | disclosed |