Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | REN | P00797 | 15/20 | 0.41 |
| ▸ | PGC | P20142 | 1/20 | 0.39 |
| ▸ | HTRA1 | Q92743 | 1/20 | 0.39 |
| ▸ | ACE | P12821 | 1/20 | 0.38 |
| ▸ | PSMB1 | P20618 | 1/20 | 0.38 |
| ▸ | PSMB8 | P28062 | 1/20 | 0.38 |
| ▸ | PSMB9 | P28065 | 1/20 | 0.38 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.38 |
| ▸ | PSMB10 | P40306 | 1/20 | 0.38 |
| ▸ | PSMB2 | P49721 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7320145 | 0.89 | REN (0.40) | RENPGCACEPSMB1PSMB8 | |
| SCHEMBL7320165 | 0.89 | REN (0.40) | RENPGCACEPSMB1PSMB8 | |
| SCHEMBL7321725 | 0.87 | REN (0.45) | REN | |
| SCHEMBL7321722 | 0.86 | REN (0.43) | REN | |
| SCHEMBL7319388 | 0.86 | REN (0.39) | RENPGCACEPSMB1PSMB8 | |
| SCHEMBL7320914 | 0.82 | REN (0.47) | RENPGC | |
| SCHEMBL7399224 | 0.80 | REN (0.55) | RENPGC | |
| SCHEMBL7314808 | 0.79 | REN (0.36) | RENPGCHTRA1ACEPSMB1 | |
| SCHEMBL7319600 | 0.79 | REN (0.36) | RENPGCHTRA1ACEPSMB1 | |
| SCHEMBL7309951 | 0.77 | REN (0.35) | REN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0231919-B1 | N-HETEROCYCLIC ALCOHOL RENIN INHIBITORS | E.R. Squibb & Sons, Inc. (US) | 1993-01-20 | — | — | EP | disclosed |
| EP-0231919-A2 | N-Heterocyclic alcohol renin inhibitors | E.R. Squibb & Sons, Inc. (US) | 1987-08-12 | — | — | EP | disclosed |