⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL789169 | 0.80 | — | — | |
| SCHEMBL790463 | 0.80 | — | — | |
| SCHEMBL15064155 | 0.80 | — | — | |
| SCHEMBL790491 | 0.80 | — | — | |
| SCHEMBL3696578 | 0.80 | — | — | |
| SCHEMBL19730165 | 0.73 | — | — | |
| SCHEMBL18902422 | 0.69 | POLB (0.33) | — | |
| SCHEMBL14629631 | 0.69 | POLB (0.33) | — | |
| SCHEMBL11288135 | 0.67 | — | — | |
| SCHEMBL11287030 | 0.67 | ALDH1A1 (0.31) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20160208101-A1 | NOVEL RHODAMINE DYES AND CONJUGATES | PHARMACOPHOTONICS, INC. D/B/A FAST DIAGNOSTICS | 2016-07-21 | — | — | US | disclosed |
| US-9040563-B2 | Dual inhibitors of farnesyltransferase and geranylgeranyltransferase I | H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC. (US) | 2015-05-26 | — | — | US | disclosed |
| US-20140288323-A1 | CYCLOPROPENIMINE CATALYST COMPOSITIONS AND PROCESSES | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2014-09-25 | — | — | US | disclosed |
| US-5288731-A | Antiemetics, antiserotonine agents | RHONE-POULENC RORER PHARMACEUTICALS INC. (US) | 1994-02-22 | — | — | US | disclosed |
| US-5246942-A | Central nervous system, anti-emetic and gastric prokinetic activity | RHONE-POULENC RORER PHARMACEUTICALS INC. (US) | 1993-09-21 | — | — | US | disclosed |
| EP-0494140-A4 | DIBENZOFURANCARBOXAMIDES | — | 1992-09-02 | — | — | EP | disclosed |
| EP-0494140-A1 | DIBENZOFURANCARBOXAMIDES | RORER INTERNATIONAL (HOLDINGS), INC. (US) | 1992-07-15 | — | — | EP | disclosed |
| WO-1992009284-A1 | 2,6-METHANO-2H-1-BENZOXOCINCARBOXAMIDES AS 5-HT3-ANTAGONISTS | RHONE-POULENC RORER INTERNATIONAL (HOLDINGS), INC. (US) | 1992-06-11 | — | — | WO | disclosed |
| WO-1991004738-A1 | DIBENZOFURANCARBOXAMIDES | RORER INTERNATIONAL (HOLDINGS), INC. (US) | 1991-04-18 | — | — | WO | disclosed |
| US-4959485-A | 5-HT3 ANTAGONISTS | RORER PHARMACEUTICAL CORPORATION (US) | 1990-09-25 | — | — | US | disclosed |
| WO-1989010364-A1 | DIBENZOFURANCARBOXAMIDES | RORER INTERNATIONAL (OVERSEAS) INC. (US) | 1989-11-02 | — | — | WO | disclosed |
| EP-0339950-A2 | Dibenzofurancarboxamides, their use as pharmaceutical agents, a composition containing the same, and a process for the preparation thereof | RHONE-POULENC RORER INTERNATIONAL (HOLDINGS) INC. (US) | 1989-11-02 | — | — | EP | disclosed |
| US-4863921-A | Dibenzofurancarboxamides and their pharmaceutical compositions and methods | RORER PHARMACEUTICAL CORPORATION (US) | 1989-09-05 | — | — | US | disclosed |