Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK1 | Q13464 | 9/20 | 0.53 |
| ▸ | ROCK2 | O75116 | 7/20 | 0.53 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | FLT3 | P36888 | 3/20 | 0.45 |
| ▸ | PRKD3 | O94806 | 2/20 | 0.44 |
| ▸ | PRKCG | P05129 | 2/20 | 0.44 |
| ▸ | PRKCB | P05771 | 2/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.44 |
| ▸ | PRKCA | P17252 | 2/20 | 0.44 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.44 |
| ▸ | PRKCH | P24723 | 2/20 | 0.44 |
| ▸ | PRKCI | P41743 | 2/20 | 0.44 |
| ▸ | PRKCE | Q02156 | 2/20 | 0.44 |
| ▸ | PRKCQ | Q04759 | 2/20 | 0.44 |
| ▸ | PRKCZ | Q05513 | 2/20 | 0.44 |
| ▸ | PRKCD | Q05655 | 2/20 | 0.44 |
| ▸ | PRKD1 | Q15139 | 2/20 | 0.44 |
| ▸ | GLA | P06280 | 1/20 | 0.44 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7319670 | 0.90 | ROCK2 (0.54) | ROCK1ROCK2TSHRFLT3PRKD3 | |
| SCHEMBL7326840 | 0.90 | ROCK2 (0.54) | ROCK1ROCK2TSHRFLT3PRKD3 | |
| SCHEMBL7319000 | 0.90 | ROCK2 (0.54) | ROCK1ROCK2TSHRFLT3PRKD3 | |
| SCHEMBL7323341 | 0.90 | ROCK2 (0.54) | ROCK1ROCK2TSHRFLT3PRKD3 | |
| SCHEMBL7326654 | 0.90 | ROCK2 (0.54) | ROCK1ROCK2TSHRFLT3PRKD3 | |
| SCHEMBL10980097 | 0.90 | TSHR (0.55) | ROCK1ROCK2TSHRFLT3PRKD3 | |
| SCHEMBL4725908 | 0.89 | ROCK2 (0.56) | ROCK1ROCK2TSHRFLT3PRKD3 | |
| SCHEMBL4729428 | 0.89 | ROCK2 (0.56) | ROCK1ROCK2TSHRFLT3PRKD3 | |
| SCHEMBL4727732 | 0.89 | ROCK2 (0.56) | ROCK1ROCK2TSHRFLT3PRKD3 | |
| SCHEMBL4728375 | 0.89 | ROCK2 (0.56) | ROCK1ROCK2TSHRFLT3PRKD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0287696-B1 | ISOQUINOLINE DERIVATIVES | Asahi Kasei Kogyo Kabushiki Kaisha (JP) | 1991-01-02 | — | — | EP | disclosed |
| US-4798897-A | (AMINOALKYL)AMINOSULFONYL-SUBSTITUTED CARDIOVASCULAR AND RESPIRATORY SYSTEM DISORDERS | ASAHI KASEI KOGYO KABUSHIKI KAISHA (JP) | 1989-01-17 | — | — | US | disclosed |
| EP-0287696-A1 | Isoquinoline derivatives | Asahi Kasei Kogyo Kabushiki Kaisha (JP) | 1988-10-26 | — | — | EP | disclosed |