Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.59 |
| ▸ | LMNA | P02545 | 3/20 | 0.59 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.59 |
| ▸ | GAA | P10253 | 1/20 | 0.56 |
| ▸ | HPGD | P15428 | 1/20 | 0.56 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.53 |
| ▸ | POLB | P06746 | 2/20 | 0.51 |
| ▸ | GRM5 | P41594 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31106406 | 0.87 | NPC1 (0.60) | MAPTLMNAKDM4EGAAHPGD | |
| SCHEMBL11176491 | 0.82 | MAPT (0.56) | MAPTLMNAKDM4EGAAHPGD | |
| SCHEMBL17584869 | 0.82 | MAPT (0.53) | MAPTLMNAKDM4EGAAHPGD | |
| SCHEMBL14498799 | 0.82 | ALDH1A1 (0.60) | MAPTLMNAKDM4EGAAHPGD | |
| SCHEMBL8252500 | 0.82 | ALDH1A1 (0.60) | MAPTLMNAKDM4EGAAHPGD | |
| SCHEMBL8242997 | 0.82 | ALDH1A1 (0.60) | MAPTLMNAKDM4EGAAHPGD | |
| SCHEMBL8253033 | 0.82 | NPC1 (0.54) | MAPTLMNAKDM4EGAAHPGD | |
| SCHEMBL8243019 | 0.82 | NPC1 (0.54) | MAPTLMNAKDM4EGAAHPGD | |
| SCHEMBL8253035 | 0.82 | NPC1 (0.54) | MAPTLMNAKDM4EGAAHPGD | |
| SCHEMBL1794728 | 0.81 | HRH3 (0.61) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0610192-A1 | ETHER DERIVATIVES OF ALKYL PIPERIDINES AND PYRROLIDINES AS ANTIPSYCHOTIC AGENTS | THE DU PONT MERCK PHARMACEUTICAL COMPANY (US) | 1994-08-17 | — | — | EP | disclosed |
| US-5317024-A | Administering to mammals | DUPONT MERCK PHARMACEUTICAL CO. (US) | 1994-05-31 | — | — | US | disclosed |
| US-5252586-A | Ether derivatives of alkyl piperidines and pyrrolidines as antipsychotic agents | THE DU PONT MERCK PHARMACEUTICAL COMPANY (US) | 1993-10-12 | — | — | US | disclosed |
| WO-1993009094-A1 | ETHER DERIVATIVES OF ALKYL PIPERIDINES AND PYRROLIDINES AS ANTIPSYCHOTIC AGENTS | THE DU PONT MERCK PHARMACEUTICAL COMPANY (US) | 1993-05-13 | — | — | WO | disclosed |