Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCKAR | P32238 | 4/20 | 0.36 |
| ▸ | CCKBR | P32239 | 4/20 | 0.36 |
| ▸ | SCN9A | Q15858 | 4/20 | 0.36 |
| ▸ | REN | P00797 | 1/20 | 0.34 |
| ▸ | PPARA | Q07869 | 1/20 | 0.33 |
| ▸ | AKT1 | P31749 | 1/20 | 0.33 |
| ▸ | CTSS | P25774 | 3/20 | 0.32 |
| ▸ | CTSL | P07711 | 1/20 | 0.32 |
| ▸ | CTSB | P07858 | 1/20 | 0.32 |
| ▸ | CTSK | P43235 | 1/20 | 0.32 |
| ▸ | PSMB1 | P20618 | 1/20 | 0.32 |
| ▸ | PSMB8 | P28062 | 1/20 | 0.32 |
| ▸ | PSMB9 | P28065 | 1/20 | 0.32 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.32 |
| ▸ | PSMB10 | P40306 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7318476 | 1.00 | CCKAR (0.36) | CCKARCCKBRSCN9ARENPPARA | |
| SCHEMBL7319648 | 0.90 | CCKAR (0.36) | CCKARCCKBRSCN9ARENPPARA | |
| SCHEMBL7319600 | 0.86 | REN (0.36) | CCKARCCKBRSCN9ARENPSMB1 | |
| SCHEMBL7314808 | 0.86 | REN (0.36) | CCKARCCKBRSCN9ARENPSMB1 | |
| SCHEMBL7373403 | 0.79 | REN (0.35) | CCKARCCKBRRENPPARACTSS | |
| SCHEMBL7321725 | 0.78 | REN (0.45) | REN | |
| SCHEMBL7319388 | 0.78 | REN (0.39) | RENCTSSCTSLCTSBCTSK | |
| SCHEMBL10785485 | 0.77 | REN (0.42) | CCKARCCKBRSCN9ARENAKT1 | |
| SCHEMBL7324681 | 0.77 | REN (0.41) | CCKARCCKBRRENCTSSCTSL | |
| SCHEMBL7313196 | 0.77 | REN (0.41) | CCKARCCKBRRENCTSSCTSL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0231919-B1 | N-HETEROCYCLIC ALCOHOL RENIN INHIBITORS | E.R. Squibb & Sons, Inc. (US) | 1993-01-20 | — | — | EP | disclosed |
| EP-0231919-A2 | N-Heterocyclic alcohol renin inhibitors | E.R. Squibb & Sons, Inc. (US) | 1987-08-12 | — | — | EP | disclosed |