Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACE | P12821 | 12/20 | 0.77 |
| ▸ | LMNA | P02545 | 1/20 | 0.63 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.58 |
| ▸ | LTA4H | P09960 | 2/20 | 0.56 |
| ▸ | MME | P08473 | 1/20 | 0.55 |
| ▸ | ACE2 | Q9BYF1 | 2/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7324352 | 0.91 | ACE (0.77) | ACELMNASMN1; SMN2LTA4H | |
| SCHEMBL7333973 | 0.90 | ACE (0.81) | ACELMNASMN1; SMN2LTA4H | |
| SCHEMBL7321736 | 0.90 | ACE (0.76) | ACELMNASMN1; SMN2LTA4H | |
| SCHEMBL7325642 | 0.90 | ACE (0.76) | ACELMNASMN1; SMN2LTA4H | |
| SCHEMBL24506200 | 0.89 | ACE (0.77) | ACELMNASMN1; SMN2 | |
| SCHEMBL11204194 | 0.89 | ACE (0.87) | ACELMNASMN1; SMN2 | |
| SCHEMBL11199445 | 0.89 | ACE (0.87) | ACELMNASMN1; SMN2 | |
| SCHEMBL11262743 | 0.89 | ACE (0.77) | ACELMNASMN1; SMN2LTA4H | |
| SCHEMBL11267471 | 0.89 | ACE (0.77) | ACELMNASMN1; SMN2LTA4H | |
| SCHEMBL7323369 | 0.89 | ACE (0.70) | ACELMNASMN1; SMN2LTA4H |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4472380-A | CARBOXYALKYL DIPEPTIDE DERIVATIVES | MERCK & CO., INC. (US) | 1984-09-18 | — | — | US | disclosed |
| US-4374829-A | Aminoacid derivatives as antihypertensives | MERCK & CO., INC. (US) | 1983-02-22 | — | — | US | disclosed |
| EP-0012401-A1 | Carboxyalkyl dipeptide derivatives, process for preparing them and pharmaceutical composition containing them | MERCK & CO. INC. (US) | 1980-06-25 | — | — | EP | disclosed |