Known targets — ChEMBL curated mechanism
PPARDPTGS1PTGS2dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Benzil. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS1 known ✓ | P23219 | 1/20 | 0.44 |
| ▸ | GSR | P00390 | 1/20 | 0.67 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.51 |
| ▸ | DPP7 | Q9UHL4 | 2/20 | 0.50 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.50 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.50 |
| ▸ | MMP2 | P08253 | 1/20 | 0.49 |
| ▸ | CES2 | O00748 | 2/20 | 0.47 |
| ▸ | CES1 | P23141 | 2/20 | 0.47 |
| ▸ | KIF11 | P52732 | 3/20 | 0.46 |
| ▸ | ALPI | P09923 | 1/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | XIAP | P98170 | 1/20 | 0.44 |
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.44 |
| ▸ | LTA4H | P09960 | 1/20 | 0.44 |
| ▸ | NOS1 | P29475 | 1/20 | 0.44 |
| ▸ | ARG1 | P05089 | 1/20 | 0.43 |
| ▸ | ARG2 | P78540 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Benzophenone SCHEMBL6349309 | 0.90 | GSR (0.67) | GSRPOLBKMT2ATDP1DPP7 | |
| Lysine SCHEMBL3907029 | 0.89 | GSR (0.65) | GSRPOLBKMT2ATDP1DPP7 | |
| Lysine SCHEMBL28623413 | 0.89 | GSR (0.65) | GSRPOLBKMT2ATDP1DPP7 | |
| Lysine SCHEMBL28960644 | 0.89 | GSR (0.65) | GSRPOLBKMT2ATDP1DPP7 | |
| Lysine SCHEMBL28623414 | 0.89 | GSR (0.65) | GSRPOLBKMT2ATDP1DPP7 | |
| Lysine SCHEMBL28616703 | 0.87 | GSR (0.62) | GSRPOLBKMT2ATDP1DPP7 | |
| Lysine SCHEMBL28616706 | 0.87 | GSR (0.62) | GSRPOLBKMT2ATDP1DPP7 | |
| Lysine SCHEMBL29288699 | 0.87 | GSR (0.62) | GSRPOLBKMT2ATDP1DPP7 | |
| Lysine SCHEMBL29288698 | 0.87 | GSR (0.62) | GSRPOLBKMT2ATDP1DPP7 | |
| Lysine SCHEMBL28922053 | 0.87 | GSR (0.62) | GSRPOLBKMT2ATDP1DPP7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4691007-A | HUMAN LEUKOCYTE ELASTASE INHIBITORS | ICI AMERICAS INC. (US) | 1987-09-01 | — | — | US | disclosed |
| US-4596789-A | Pharmaceuticals | ICI AMERICAS INC. (US) | 1986-06-24 | — | — | US | disclosed |
| EP-0124317-A2 | Proline derivatives | ICI AMERICAS INC. (US) | 1984-11-07 | — | — | EP | disclosed |