Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGB3 | P05106 | 1/20 | 0.67 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.67 |
| ▸ | KLK7 | P49862 | 2/20 | 0.57 |
| ▸ | KLK5 | Q9Y337 | 2/20 | 0.57 |
| ▸ | ACE | P12821 | 3/20 | 0.57 |
| ▸ | MAPT | P10636 | 1/20 | 0.54 |
| ▸ | DPP4 | P27487 | 2/20 | 0.53 |
| ▸ | DPP8 | Q6V1X1 | 2/20 | 0.53 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.53 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.53 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.52 |
| ▸ | CMA1 | P23946 | 2/20 | 0.50 |
| ▸ | HTRA1 | Q92743 | 1/20 | 0.50 |
| ▸ | F2 | P00734 | 1/20 | 0.49 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.49 |
| ▸ | F13A1 | P00488 | 1/20 | 0.49 |
| ▸ | TGM2 | P21980 | 1/20 | 0.49 |
| ▸ | TGM1 | P22735 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7322422 | 0.97 | ITGB3 (0.64) | ITGB3ITGA2BKLK7KLK5ACE | |
| SCHEMBL11017398 | 0.97 | ITGB3 (0.63) | ITGB3ITGA2BKLK7KLK5ACE | |
| SCHEMBL5971737 | 0.94 | ITGB3 (0.66) | ITGB3ITGA2BKLK7KLK5ACE | |
| SCHEMBL7321814 | 0.94 | ITGB3 (0.65) | ITGB3ITGA2BKLK7KLK5ACE | |
| SCHEMBL16215777 | 0.92 | ITGB3 (0.63) | ITGB3ITGA2BKLK7KLK5ACE | |
| SCHEMBL10619564 | 0.92 | ITGB3 (0.63) | ITGB3ITGA2BKLK7KLK5ACE | |
| SCHEMBL17460683 | 0.92 | ITGB3 (0.63) | ITGB3ITGA2BKLK7KLK5ACE | |
| SCHEMBL13599692 | 0.91 | ITGB3 (0.62) | ITGB3ITGA2BKLK7KLK5ACE | |
| SCHEMBL7309936 | 0.91 | ITGB3 (0.59) | ITGB3ITGA2BKLK7KLK5ACE | |
| SCHEMBL7325125 | 0.91 | ITGB3 (0.62) | ITGB3ITGA2BKLK7KLK5ACE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4691007-A | HUMAN LEUKOCYTE ELASTASE INHIBITORS | ICI AMERICAS INC. (US) | 1987-09-01 | — | — | US | disclosed |
| US-4596789-A | Pharmaceuticals | ICI AMERICAS INC. (US) | 1986-06-24 | — | — | US | disclosed |
| EP-0132304-A2 | Hydroxy substituted peptide compounds | E.R. Squibb & Sons, Inc. (US) | 1985-01-30 | — | — | EP | disclosed |
| EP-0124317-A2 | Proline derivatives | ICI AMERICAS INC. (US) | 1984-11-07 | — | — | EP | disclosed |
| EP-0071544-A1 | Phosphonamidate compounds | E.R. Squibb & Sons, Inc. (US) | 1983-02-09 | — | — | EP | disclosed |