Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD3 | P35462 | 5/20 | 0.66 |
| ▸ | DRD2 | P14416 | 4/20 | 0.66 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.61 |
| ▸ | DRD4 | P21917 | 3/20 | 0.61 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.61 |
| ▸ | PRCP | P42785 | 1/20 | 0.61 |
| ▸ | EBP | Q15125 | 1/20 | 0.61 |
| ▸ | HTR1A | P08908 | 1/20 | 0.51 |
| ▸ | DRD1 | P21728 | 1/20 | 0.51 |
| ▸ | DRD5 | P21918 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11270759 | 0.85 | DRD3 (0.53) | DRD3DRD2SIGMAR1DRD4NFKB1 | |
| SCHEMBL26287153 | 0.85 | DRD3 (0.50) | DRD3DRD2SIGMAR1DRD4NFKB1 | |
| SCHEMBL2389123 | 0.82 | DRD2 (0.60) | DRD3DRD2DRD4HTR1ADRD1 | |
| SCHEMBL21323287 | 0.82 | DRD2 (0.63) | DRD3DRD2DRD4DRD1DRD5 | |
| SCHEMBL2603277 | 0.82 | DRD2 (0.63) | DRD3DRD2DRD4DRD1DRD5 | |
| SCHEMBL17658922 | 0.82 | DRD2 (0.63) | DRD3DRD2DRD4DRD1DRD5 | |
| SCHEMBL11624785 | 0.81 | DRD2 (0.56) | DRD3DRD2 | |
| SCHEMBL24310013 | 0.81 | DRD3 (0.70) | DRD3DRD2SIGMAR1DRD4NFKB1 | |
| SCHEMBL7354726 | 0.81 | DRD3 (0.70) | DRD3DRD2SIGMAR1DRD4NFKB1 | |
| SCHEMBL29567496 | 0.81 | DRD3 (0.70) | DRD3DRD2SIGMAR1DRD4NFKB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4426386-A | CNS DISORDERS | ASTRA LAKEMEDEL AKTIEBOLAG (SE) | 1984-01-17 | — | — | US | claimed |
| EP-0030526-A1 | New phenyl-azacycloalkanes, processes for preparation and pharmaceutical preparations for such compounds | Astra Läkemedel Aktiebolag (SE) | 1981-06-17 | — | — | EP | claimed |
| WO-1981001552-A1 | NEW PHENYL-AZACYCLOALKANES | ASTRA LAEKEMEDEL AB (SE) | 1981-06-11 | — | — | WO | claimed |
| EP-3765447-B1 | TRIAZACYCLODODECANSULFONAMIDE (\"TCD\")-BASED PROTEIN SECRETION INHIBITORS | KEZAR LIFE SCIENCES (US) | 2023-07-12 | — | — | EP | disclosed |
| US-4937346-A | Phenyl-azacykloalkanes | Carlsson, Per Arvid Emil (SE) | 1990-06-26 | — | — | US | disclosed |
| EP-0084920-B1 | NEW COMPOUNDS USEFUL AS INTERMEDIATES OR STARTING MATERIALS FOR PREPARATION OF THERAPEUTICALLY USEFUL PHENYL-AZACYCLOALKANES | Carlsson, Per Arvid Emil (SE) | 1989-04-19 | — | — | EP | disclosed |
| US-4719219-A | Phenyl-azacycloalkanes and use thereof in treatment of central nervous system disorders | Carlsson, Per A. E. (SE) | 1988-01-12 | — | — | US | disclosed |
| US-4426386-A | CNS DISORDERS | ASTRA LAKEMEDEL AKTIEBOLAG (SE) | 1984-01-17 | — | — | US | disclosed |
| EP-0084920-A2 | New compounds useful as intermediates or starting materials for preparation of therapeutically useful phenyl-azacycloalkanes | Carlsson, Per Arvid Emil (SE) | 1983-08-03 | — | — | EP | disclosed |
| EP-0030526-A1 | New phenyl-azacycloalkanes, processes for preparation and pharmaceutical preparations for such compounds | Astra Läkemedel Aktiebolag (SE) | 1981-06-17 | — | — | EP | disclosed |
| WO-1981001552-A1 | NEW PHENYL-AZACYCLOALKANES | ASTRA LAEKEMEDEL AB (SE) | 1981-06-11 | — | — | WO | disclosed |