Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIF11 | P52732 | 12/20 | 0.40 |
| ▸ | SLC1A5 | Q15758 | 2/20 | 0.37 |
| ▸ | BCHE | P06276 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | EDNRB | P24530 | 1/20 | 0.33 |
| ▸ | EDNRA | P25101 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7326141 | 0.88 | KIF11 (0.42) | KIF11SLC1A5MEN1KMT2A | |
| SCHEMBL7326447 | 0.87 | KIF11 (0.47) | KIF11SLC1A5EDNRBEDNRALMNA | |
| SCHEMBL7323108 | 0.87 | KIF11 (0.47) | KIF11SLC1A5MEN1KMT2A | |
| SCHEMBL7314762 | 0.85 | KIF11 (0.51) | KIF11SLC1A5 | |
| SCHEMBL7320451 | 0.84 | KIF11 (0.40) | KIF11SLC1A5EDNRBEDNRALMNA | |
| SCHEMBL7322275 | 0.84 | KIF11 (0.40) | KIF11SLC1A5EDNRBEDNRALMNA | |
| SCHEMBL7315875 | 0.78 | KIF11 (0.58) | KIF11 | |
| SCHEMBL7315871 | 0.78 | KIF11 (0.58) | KIF11 | |
| SCHEMBL7311886 | 0.74 | KIF11 (0.43) | KIF11SLC1A5MEN1KMT2A | |
| SCHEMBL7314907 | 0.74 | KIF11 (0.55) | KIF11SLC1A5MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1999041227-A1 | TRICYCLIC COMPOUNDS AS GLYCINE TRANSPORT INHIBITORS | ALLELIX NEUROSCIENCE, INC. (US) | 1999-08-19 | — | — | WO | claimed |
| US-6162824-A | NERVOUS SYSTEM DISORDERS; PSYCHOLOGICAL DISORDERS | ALLELIX NEUROSCIENCE INC. | 2000-12-19 | — | — | US | disclosed |
| WO-1999041227-A1 | TRICYCLIC COMPOUNDS AS GLYCINE TRANSPORT INHIBITORS | ALLELIX NEUROSCIENCE, INC. (US) | 1999-08-19 | — | — | WO | disclosed |