Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 3/20 | 0.73 |
| ▸ | RAB9A | P51151 | 3/20 | 0.73 |
| ▸ | MEN1 | O00255 | 2/20 | 0.73 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.73 |
| ▸ | CHRM2 | P08172 | 3/20 | 0.54 |
| ▸ | CHRM4 | P08173 | 3/20 | 0.54 |
| ▸ | CHRM1 | P11229 | 3/20 | 0.54 |
| ▸ | CHRM3 | P20309 | 3/20 | 0.54 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | SPHK2 | Q9NRA0 | 1/20 | 0.48 |
| ▸ | PREP | P48147 | 2/20 | 0.48 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10664146 | 1.00 | NPC1 (0.73) | NPC1RAB9AMEN1KMT2ACHRM2 | |
| SCHEMBL10667403 | 0.96 | NPC1 (0.67) | NPC1RAB9AMEN1KMT2ACHRM2 | |
| SCHEMBL10667407 | 0.96 | NPC1 (0.67) | NPC1RAB9AMEN1KMT2ACHRM2 | |
| SCHEMBL11078570 | 0.95 | NPC1 (0.66) | NPC1RAB9AMEN1KMT2ACHRM2 | |
| SCHEMBL10508873 | 0.95 | NPC1 (0.66) | NPC1RAB9AMEN1KMT2ACHRM2 | |
| SCHEMBL7284566 | 0.92 | NPC1 (0.63) | NPC1RAB9AMEN1KMT2ACHRM2 | |
| SCHEMBL10509164 | 0.92 | NPC1 (0.61) | NPC1RAB9AMEN1KMT2ACHRM2 | |
| SCHEMBL10509156 | 0.92 | NPC1 (0.61) | NPC1RAB9AMEN1KMT2ACHRM2 | |
| SCHEMBL9774323 | 0.84 | PREP (0.66) | NPC1RAB9AMEN1KMT2ACHRM2 | |
| SCHEMBL15473538 | 0.83 | FFAR1 (0.55) | NPC1RAB9AMEN1KMT2ACHRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4743616-A | ANTIAMNESIA AGENTS | SUNTORY LIMITED (JP) | 1988-05-10 | — | — | US | disclosed |
| EP-0105919-B1 | 1-CARBOXYALKANOYLPERHYDROINDOLE-2-CARBOXYLIC ACIDS AND DERIVATIVES | CIBA-GEIGY AG (CH) | 1987-07-08 | — | — | EP | disclosed |
| EP-0172458-A2 | Novel biologically active compound having anti-prolyl endopeptidase activity | SUNTORY LIMITED (JP) | 1986-02-26 | — | — | EP | disclosed |
| US-4479963-A | HYPOTENSIVE AGENTS | CIBA-GEIGY CORPORATION (US) | 1984-10-30 | — | — | US | disclosed |
| EP-0105919-A1 | 1-CARBOXYALKANOYLPERHYDROINDOLE-2-CARBOXYLIC ACIDS AND DERIVATIVES. | CIBA GEIGY AG (CH) | 1984-04-25 | — | — | EP | disclosed |
| WO-1983003828-A1 | 1-CARBOXYALKANOYLPERHYDROINDOLE-2-CARBOXYLIC ACIDS AND DERIVATIVES | CIBA-GEIGY AG (CH) | 1983-11-10 | — | — | WO | disclosed |
| US-4374847-A | HYPOTENSIVE AGENTS | CIBA-GEIGY CORPORATION (US) | 1983-02-22 | — | — | US | disclosed |
| EP-0050850-A1 | 1-Carboxyalkanoylindolin-2-carboxylic acids and derivatives thereof, processes for their preparation, and pharmaceutical compositions containing these compounds | CIBA-GEIGY AG (CH) | 1982-05-05 | — | — | EP | disclosed |