Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 4/20 | 0.67 |
| ▸ | ORAI1 | Q96D31 | 3/20 | 0.66 |
| ▸ | TRPC3 | Q13507 | 3/20 | 0.66 |
| ▸ | TRPC1 | P48995 | 1/20 | 0.66 |
| ▸ | STIM1 | Q13586 | 1/20 | 0.66 |
| ▸ | MAPT | P10636 | 4/20 | 0.64 |
| ▸ | TRPC5 | Q9UL62 | 1/20 | 0.59 |
| ▸ | CRACR2A | Q9BSW2 | 1/20 | 0.57 |
| ▸ | THRB | P10828 | 3/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.53 |
| ▸ | P2RX1 | P51575 | 2/20 | 0.52 |
| ▸ | P2RX4 | Q99571 | 1/20 | 0.52 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.52 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.50 |
| ▸ | LMNA | P02545 | 2/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7326834 | 0.89 | ORAI1 (0.75) | TP53ORAI1TRPC3TRPC1STIM1 | |
| SCHEMBL7323681 | 0.89 | KDM4E (0.69) | TP53ORAI1TRPC3TRPC1STIM1 | |
| SCHEMBL7320077 | 0.89 | TP53 (0.67) | TP53ORAI1TRPC3TRPC1STIM1 | |
| SCHEMBL7326819 | 0.88 | TP53 (0.66) | TP53ORAI1TRPC3TRPC1STIM1 | |
| SCHEMBL7320259 | 0.88 | ORAI1 (0.69) | TP53ORAI1TRPC3TRPC1STIM1 | |
| SCHEMBL7318779 | 0.88 | TP53 (0.66) | TP53ORAI1TRPC3TRPC1STIM1 | |
| SCHEMBL7234017 | 0.88 | TP53 (0.86) | TP53ORAI1TRPC3TRPC1STIM1 | |
| SCHEMBL7317024 | 0.88 | TP53 (0.66) | TP53ORAI1TRPC3TRPC1STIM1 | |
| SCHEMBL7328795 | 0.88 | TP53 (0.69) | TP53ORAI1TRPC3TRPC1STIM1 | |
| SCHEMBL3277387 | 0.86 | ORAI1 (0.73) | TP53ORAI1TRPC3TRPC1STIM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20010044445-A1 | AZOLE INHIBITORS OF CYTOKINE PRODUCTION | ABBOTT LABORATORIES | 2001-11-22 | — | — | US | claimed |
| US-20010044445-A1 | AZOLE INHIBITORS OF CYTOKINE PRODUCTION | ABBOTT LABORATORIES | 2001-11-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20010044445-A1 | AZOLE INHIBITORS OF CYTOKINE PRODUCTION | IL5, IL2, IL4 | TP53 1903/4885ORAI1 3522/4885TRPC3 4362/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.