Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 | P00915 | 2/20 | 0.46 |
| ▸ | CA2 | P00918 | 2/20 | 0.46 |
| ▸ | CA4 | P22748 | 2/20 | 0.46 |
| ▸ | SLC6A12 | P48065 | 5/20 | 0.44 |
| ▸ | SLC6A11 | P48066 | 5/20 | 0.44 |
| ▸ | SLC6A13 | Q9NSD5 | 5/20 | 0.44 |
| ▸ | PTGS1 | P23219 | 7/20 | 0.38 |
| ▸ | PTGS2 | P35354 | 6/20 | 0.38 |
| ▸ | MT-CO1 | P00395 | 1/20 | 0.38 |
| ▸ | MT-CO2 | P00403 | 1/20 | 0.38 |
| ▸ | SLC18A3 | Q16572 | 2/20 | 0.35 |
| ▸ | SLC6A1 | P30531 | 2/20 | 0.34 |
| ▸ | GABRA5 | P31644 | 2/20 | 0.34 |
| ▸ | GABRB2 | P47870 | 2/20 | 0.34 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.34 |
| ▸ | GABRR1 | P24046 | 1/20 | 0.34 |
| ▸ | GABRA4 | P48169 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4112861 | 1.00 | CA1 (0.46) | CA1CA2CA4SLC6A12SLC6A11 | |
| SCHEMBL4112857 | 1.00 | CA1 (0.46) | CA1CA2CA4SLC6A12SLC6A11 | |
| SCHEMBL4127933 | 1.00 | CA1 (0.46) | CA1CA2CA4SLC6A12SLC6A11 | |
| SCHEMBL25662275 | 1.00 | CA1 (0.46) | CA1CA2CA4SLC6A12SLC6A11 | |
| SCHEMBL4112859 | 1.00 | CA1 (0.46) | CA1CA2CA4SLC6A12SLC6A11 | |
| SCHEMBL19336874 | 1.00 | CA1 (0.46) | CA1CA2CA4SLC6A12SLC6A11 | |
| SCHEMBL4127935 | 1.00 | CA1 (0.46) | CA1CA2CA4SLC6A12SLC6A11 | |
| SCHEMBL4120941 | 0.95 | SLC6A12 (0.44) | CA1CA2CA4SLC6A12SLC6A11 | |
| SCHEMBL9294224 | 0.95 | SLC6A12 (0.44) | CA1CA2CA4SLC6A12SLC6A11 | |
| SCHEMBL4120944 | 0.95 | SLC6A12 (0.44) | CA1CA2CA4SLC6A12SLC6A11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0658169-A1 | DIAMINO ACID DERIVATIVES AS ANTIHYPERTENSIVES | SCHERING CORPORATION (US) | 1995-06-21 | — | — | EP | disclosed |
| US-5298492-A | Inhibitors of endopeptidase and treatment of cardiovascular disorders | SCHERING CORPORATION (US) | 1994-03-29 | — | — | US | disclosed |
| WO-1994003481-A1 | DIAMINO ACID DERIVATIVES AS ANTIHYPERTENSIVES | SCHERING CORPORATION (US) | 1994-02-17 | — | — | WO | disclosed |