Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A3 | Q01959 | 4/20 | 0.50 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.50 |
| ▸ | OPRK1 | P41145 | 3/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.41 |
| ▸ | CHRM1 | P11229 | 4/20 | 0.41 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.41 |
| ▸ | CHRM4 | P08173 | 2/20 | 0.41 |
| ▸ | CHRM5 | P08912 | 2/20 | 0.41 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.41 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.41 |
| ▸ | HRH1 | P35367 | 2/20 | 0.41 |
| ▸ | DRD3 | P35462 | 2/20 | 0.41 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.41 |
| ▸ | DRD2 | P14416 | 1/20 | 0.41 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.41 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.41 |
| ▸ | DRD1 | P21728 | 1/20 | 0.41 |
| ▸ | HRH2 | P25021 | 1/20 | 0.41 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.41 |
| ▸ | HTR2A | P28223 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12222719 | 1.00 | SLC6A3 (0.50) | SLC6A3SLC6A2OPRK1KCNH2CHRM1 | |
| SCHEMBL1022249 | 0.84 | SLC6A3 (0.53) | SLC6A3SLC6A2OPRK1KCNH2CHRM1 | |
| SCHEMBL1177891 | 0.84 | SLC6A3 (0.51) | SLC6A3SLC6A2OPRK1KCNH2CHRM1 | |
| SCHEMBL746296 | 0.84 | SLC6A2 (0.49) | SLC6A3SLC6A2OPRK1KCNH2CHRM1 | |
| SCHEMBL1022248 | 0.84 | SLC6A3 (0.53) | SLC6A3SLC6A2OPRK1KCNH2CHRM1 | |
| SCHEMBL746295 | 0.84 | SLC6A2 (0.49) | SLC6A3SLC6A2OPRK1KCNH2CHRM1 | |
| SCHEMBL1177892 | 0.84 | SLC6A3 (0.51) | SLC6A3SLC6A2OPRK1KCNH2CHRM1 | |
| SCHEMBL989621 | 0.84 | SLC6A2 (0.49) | SLC6A3SLC6A2OPRK1KCNH2CHRM1 | |
| SCHEMBL20958450 | 0.82 | KCNH2 (0.47) | OPRK1KCNH2 | |
| SCHEMBL20958449 | 0.82 | KCNH2 (0.47) | OPRK1KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4921860-A | Quinuclidyl- and tropanyl-pyridyl ethers as 5-HT3 receptor antagonists | JOHN WYETH AND BROTHER, LIMITED (GB) | 1990-05-01 | — | — | US | disclosed |