Predicted protein targets (top 2)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACE | P12821 | 4/20 | 0.60 |
| ▸ | LMNA | P02545 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27300918 | 1.00 | ACE (0.60) | ACELMNA | |
| SCHEMBL11031735 | 0.97 | ACE (0.61) | ACELMNA | |
| SCHEMBL11032956 | 0.93 | ACE (0.63) | ACELMNA | |
| SCHEMBL11033719 | 0.86 | ACE (0.60) | ACELMNA | |
| SCHEMBL10908203 | 0.86 | ACE (0.59) | ACELMNA | |
| SCHEMBL11032140 | 0.86 | ACE (0.55) | ACELMNA | |
| SCHEMBL10430166 | 0.84 | ACE (0.72) | ACE | |
| SCHEMBL7325900 | 0.84 | ACE (0.72) | ACE | |
| SCHEMBL11195233 | 0.83 | ACE (0.71) | ACE | |
| SCHEMBL10912494 | 0.83 | ACE (0.47) | ACELMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 23 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5037821-A | Method for inhibiting loss of cognitive functions employing a calcium channel blocker alone or in combination with an ACE inhibitor | E. R. SQUIBB & SONS, INC. (US) | 1991-08-06 | — | — | US | claimed |
| US-H734-H | Method for inhibiting onset of or treating migraine headaches employing an ACE inhibitor | E. R. SQUIBB & SONS, INC. (US) | 1990-02-06 | — | — | US | claimed |
| EP-0344995-A2 | Method for inhibiting loss of cognitive functions employing a calcium channel blocker alone or in combination with an ace inhibitor | E.R. SQUIBB & SONS, INC. (US) | 1989-12-06 | — | — | EP | claimed |
| EP-0334264-A2 | Pharmaceutical compositions for treating tardive dyskinesia employing an ace inhibitor | E.R. Squibb & Sons, Inc. (US) | 1989-09-27 | — | — | EP | claimed |
| US-4442089-A | ANGIOTENSIN CONVERTING ENZYME | E. R. SQUIBB & SONS, INC. (US) | 1984-04-10 | — | — | US | claimed |
| EP-0099239-A2 | Method for treating glaucoma | E.R. Squibb & Sons, Inc. (US) | 1984-01-25 | — | — | EP | claimed |
| US-6187752-B1 | Method for treating schizophrenia employing an ace inhibitor | E.R. SQUIBB & SONS, INC. | 2001-02-13 | — | — | US | disclosed |
| EP-0579650-A1 | NOVEL COMPOUNDS | SMITHKLINE BEECHAM PLC (GB) | 1994-01-26 | — | — | EP | disclosed |
| WO-1992017460-A1 | NOVEL COMPOUNDS | SMITHKLINE BEECHAM PLC (GB) | 1992-10-15 | — | — | WO | disclosed |
| US-5093129-A | Angiotensin converting enzyme inhibitor | E. R. SQUIBB & SONS, INC. (US) | 1992-03-03 | — | — | US | disclosed |
| EP-0381075-A2 | Method for treating addiction to a drug of abuse employing an ace inhibitor | E.R. Squibb & Sons, Inc. (US) | 1990-08-08 | — | — | EP | disclosed |
| EP-0381074-A2 | Method for facilitating dieting employing an ACE inhibitor | E.R. Squibb & Sons, Inc. (US) | 1990-08-08 | — | — | EP | disclosed |
| US-4931430-A | Method for preventing or treating anxiety employing an ACE inhibitor | E. R. SQUIBB & SONS, INC. (US) | 1990-06-05 | — | — | US | disclosed |
| EP-0321221-A2 | Method for preventing or treating anxiety employing an ace inhibitor | E.R. Squibb & Sons, Inc. (US) | 1989-06-21 | — | — | EP | disclosed |
| US-4808413-A | MIXING DRUG, ACID, BINDER, EXTRUSION AND SPHERONIZATION | E. R. SQUIBB & SONS, INC. (US) | 1989-02-28 | — | — | US | disclosed |
| EP-0288732-A2 | New pharmaceutical compositions in the form of beadlets and method | E.R. Squibb & Sons, Inc. (US) | 1988-11-02 | — | — | EP | disclosed |
| US-4442089-A | ANGIOTENSIN CONVERTING ENZYME | E. R. SQUIBB & SONS, INC. (US) | 1984-04-10 | — | — | US | disclosed |
| US-4432971-A | HYPOTENSIVE AGENTS AND ANGIOTENSIN INHIBITION | E. R. SQUIBB & SONS, INC. (US) | 1984-02-21 | — | — | US | disclosed |
| EP-0099239-A2 | Method for treating glaucoma | E.R. Squibb & Sons, Inc. (US) | 1984-01-25 | — | — | EP | disclosed |
| EP-0071544-A1 | Phosphonamidate compounds | E.R. Squibb & Sons, Inc. (US) | 1983-02-09 | — | — | EP | disclosed |