Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACE | P12821 | 10/20 | 0.60 |
| ▸ | LMNA | P02545 | 1/20 | 0.56 |
| ▸ | ACE2 | Q9BYF1 | 4/20 | 0.52 |
| ▸ | LTA4H | P09960 | 2/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7264237 | 0.90 | ACE (0.61) | ACELMNAACE2LTA4HSMN1; SMN2 | |
| SCHEMBL7264225 | 0.90 | ACE (0.61) | ACELMNAACE2LTA4HSMN1; SMN2 | |
| SCHEMBL11032956 | 0.89 | ACE (0.63) | ACELMNASMN1; SMN2 | |
| SCHEMBL11031735 | 0.87 | ACE (0.61) | ACELMNA | |
| SCHEMBL27300918 | 0.86 | ACE (0.60) | ACELMNA | |
| SCHEMBL7323523 | 0.86 | ACE (0.60) | ACELMNA | |
| SCHEMBL10929332 | 0.86 | ACE (0.57) | ACELMNAACE2LTA4HSMN1; SMN2 | |
| SCHEMBL7265475 | 0.86 | ACE (0.57) | ACELMNAACE2LTA4HSMN1; SMN2 | |
| SCHEMBL7265625 | 0.85 | ACE (0.56) | ACELMNAACE2LTA4HSMN1; SMN2 | |
| Ammonia Solution, Strong SCHEMBL10829250 | 0.85 | ACE (0.56) | ACELMNAACE2LTA4HSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4432971-A | HYPOTENSIVE AGENTS AND ANGIOTENSIN INHIBITION | E. R. SQUIBB & SONS, INC. (US) | 1984-02-21 | — | — | US | disclosed |
| EP-0071544-A1 | Phosphonamidate compounds | E.R. Squibb & Sons, Inc. (US) | 1983-02-09 | — | — | EP | disclosed |