Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 19/20 | 0.61 |
| ▸ | PDE4D | Q08499 | 3/20 | 0.53 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.53 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1388410 | 0.88 | PDE4A (0.62) | PDE4APDE4DPDE4BPDE4C | |
| SCHEMBL7391023 | 0.81 | PDE4A (0.71) | PDE4APDE4DPDE4BPDE4C | |
| SCHEMBL7321222 | 0.81 | PDE4A (0.53) | PDE4APDE4DPDE4BPDE4C | |
| SCHEMBL7312410 | 0.81 | PDE4A (0.49) | PDE4APDE4DPDE4BPDE4C | |
| SCHEMBL7355462 | 0.77 | PDE4A (0.52) | PDE4APDE4DPDE4BPDE4C | |
| SCHEMBL7608093 | 0.76 | PDE4A (1.00) | PDE4APDE4DPDE4BPDE4C | |
| SCHEMBL6758304 | 0.76 | PDE4A (1.00) | PDE4APDE4DPDE4BPDE4C | |
| SCHEMBL27726708 | 0.74 | PDE4B (0.55) | PDE4APDE4DPDE4BPDE4C | |
| SCHEMBL29061976 | 0.73 | PDE4A (0.56) | PDE4APDE4DPDE4BPDE4C | |
| SCHEMBL29061973 | 0.73 | PDE4A (0.56) | PDE4APDE4DPDE4BPDE4C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5739144-A | INHIBITORS OF PHOSPHODIESTERASE ENZYMES | CELLTECH THERAPEUTICS LIMITED (GB) | 1998-04-14 | — | — | US | disclosed |