Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 18/20 | 0.49 |
| ▸ | PDE4D | Q08499 | 3/20 | 0.49 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.49 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.49 |
| ▸ | PDE5A | O76074 | 1/20 | 0.45 |
| ▸ | PDE1A | P54750 | 1/20 | 0.45 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.45 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1388410 | 0.82 | PDE4A (0.62) | PDE4APDE4DPDE4BPDE4C | |
| SCHEMBL7323535 | 0.81 | PDE4A (0.61) | PDE4APDE4DPDE4BPDE4C | |
| SCHEMBL7321222 | 0.80 | PDE4A (0.53) | PDE4APDE4DPDE4BPDE4C | |
| SCHEMBL8578431 | 0.79 | PDE4A (0.70) | PDE4APDE4DPDE4BPDE4C | |
| SCHEMBL7355462 | 0.78 | PDE4A (0.52) | PDE4APDE4DPDE4BPDE4C | |
| SCHEMBL7391023 | 0.76 | PDE4A (0.71) | PDE4APDE4DPDE4BPDE4C | |
| Hydrochloric Acid SCHEMBL8688696 | 0.75 | PDE4A (0.64) | PDE4APDE4DPDE4BPDE4C | |
| SCHEMBL7314903 | 0.75 | ALOX15 (0.54) | PDE4APDE4DPDE4BPDE4C | |
| Hydrochloric Acid SCHEMBL7387770 | 0.74 | ALOX15 (0.53) | PDE4APDE4DPDE4BPDE4C | |
| SCHEMBL9266969 | 0.74 | PDE4A (0.56) | PDE4APDE4DPDE4BPDE4C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5962483-A | ANTIASTHMA AGENTS; ANTIINFLAMMATORY AGENTS | CELLTECH THERAPEUTICS, LIMITED (GB) | 1999-10-05 | — | — | US | disclosed |
| US-5739144-A | INHIBITORS OF PHOSPHODIESTERASE ENZYMES | CELLTECH THERAPEUTICS LIMITED (GB) | 1998-04-14 | — | — | US | disclosed |