Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ELANE | P08246 | 7/20 | 0.51 |
| ▸ | CMA1 | P23946 | 5/20 | 0.51 |
| ▸ | CAPN1 | P07384 | 2/20 | 0.50 |
| ▸ | MALT1 | Q9UDY8 | 1/20 | 0.47 |
| ▸ | CTSL | P07711 | 1/20 | 0.47 |
| ▸ | CTSB | P07858 | 1/20 | 0.47 |
| ▸ | CTSK | P43235 | 1/20 | 0.47 |
| ▸ | CCR1 | P32246 | 1/20 | 0.47 |
| ▸ | PREP | P48147 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13036084 | 0.94 | ELANE (0.55) | ELANECMA1CAPN1CTSLCTSB | |
| SCHEMBL7293993 | 0.94 | ELANE (0.55) | ELANECMA1CAPN1CTSLCTSB | |
| SCHEMBL7276583 | 0.94 | ELANE (0.55) | ELANECMA1CAPN1CTSLCTSB | |
| SCHEMBL13982069 | 0.94 | ELANE (0.55) | ELANECMA1CAPN1CTSLCTSB | |
| SCHEMBL7320470 | 0.93 | CMA1 (0.51) | ELANECMA1MALT1 | |
| Sulfurous Acid SCHEMBL7313834 | 0.91 | ELANE (0.53) | ELANECMA1CAPN1CTSLCTSB | |
| SCHEMBL7316334 | 0.91 | MALT1 (0.57) | ELANECMA1CAPN1MALT1CTSL | |
| SCHEMBL7313928 | 0.86 | CMA1 (0.55) | ELANECMA1MALT1 | |
| SCHEMBL7317148 | 0.85 | MALT1 (0.61) | ELANECMA1MALT1CTSLCTSB | |
| SCHEMBL7323606 | 0.85 | CMA1 (0.53) | ELANECMA1CAPN1MALT1CTSL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4923890-A | Difluoro keto compounds and their use as HLE inhibitors | ICI AMERICAS INC. (US) | 1990-05-08 | — | — | US | disclosed |
| EP-0249349-A1 | Difluoroketo compounds | ICI AMERICAS INC. (US) | 1987-12-16 | — | — | EP | disclosed |
| US-4691007-A | HUMAN LEUKOCYTE ELASTASE INHIBITORS | ICI AMERICAS INC. (US) | 1987-09-01 | — | — | US | disclosed |
| EP-0204571-A2 | Selected difluoro derivatives | ICI AMERICAS INC. (US) | 1986-12-10 | — | — | EP | disclosed |
| US-4596789-A | Pharmaceuticals | ICI AMERICAS INC. (US) | 1986-06-24 | — | — | US | disclosed |
| EP-0124317-A2 | Proline derivatives | ICI AMERICAS INC. (US) | 1984-11-07 | — | — | EP | disclosed |