Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CMA1 | P23946 | 5/20 | 0.53 |
| ▸ | ELANE | P08246 | 7/20 | 0.51 |
| ▸ | CAPN1 | P07384 | 2/20 | 0.51 |
| ▸ | CTSL | P07711 | 1/20 | 0.50 |
| ▸ | CTSB | P07858 | 1/20 | 0.50 |
| ▸ | CTSK | P43235 | 1/20 | 0.50 |
| ▸ | MALT1 | Q9UDY8 | 1/20 | 0.49 |
| ▸ | PREP | P48147 | 2/20 | 0.49 |
| ▸ | CCR1 | P32246 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7285949 | 1.00 | CMA1 (0.53) | CMA1ELANECAPN1CTSLCTSB | |
| SCHEMBL7320477 | 0.92 | CMA1 (0.53) | CMA1ELANEMALT1 | |
| SCHEMBL7316337 | 0.90 | MALT1 (0.59) | CMA1ELANECTSLMALT1PREP | |
| SCHEMBL7355181 | 0.88 | MALT1 (0.59) | CMA1ELANEMALT1 | |
| SCHEMBL7311225 | 0.86 | DPP8 (0.52) | CMA1ELANEMALT1 | |
| Hydrochloric Acid SCHEMBL7287630 | 0.86 | CMA1 (0.50) | CMA1ELANECAPN1CTSLCTSB | |
| SCHEMBL13036085 | 0.86 | CMA1 (0.55) | CMA1ELANEMALT1 | |
| SCHEMBL10080680 | 0.86 | ELANE (0.57) | CMA1ELANECAPN1CTSLCTSB | |
| SCHEMBL7279072 | 0.85 | CTSL (0.56) | CMA1ELANECAPN1CTSLCTSB | |
| SCHEMBL8092357 | 0.85 | CMA1 (0.58) | CMA1ELANE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4923890-A | Difluoro keto compounds and their use as HLE inhibitors | ICI AMERICAS INC. (US) | 1990-05-08 | — | — | US | disclosed |
| EP-0249349-A1 | Difluoroketo compounds | ICI AMERICAS INC. (US) | 1987-12-16 | — | — | EP | disclosed |
| US-4691007-A | HUMAN LEUKOCYTE ELASTASE INHIBITORS | ICI AMERICAS INC. (US) | 1987-09-01 | — | — | US | disclosed |
| EP-0204571-A2 | Selected difluoro derivatives | ICI AMERICAS INC. (US) | 1986-12-10 | — | — | EP | disclosed |
| US-4596789-A | Pharmaceuticals | ICI AMERICAS INC. (US) | 1986-06-24 | — | — | US | disclosed |
| EP-0124317-A2 | Proline derivatives | ICI AMERICAS INC. (US) | 1984-11-07 | — | — | EP | disclosed |