SCHEMBL7323779

SCHEMBL7323779

CCOC(=O)CCNC(=O)c1cc(I)ccc1NC(c1ccccc1)c1ccccc1

nearest known ligand 0.43

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ADORA3 P0DMS8 1/20 0.43
CYP3A4 P08684 1/20 0.42
CYP2D6 P10635 1/20 0.42
CYP2C19 P33261 1/20 0.42
NPSR1 Q6W5P4 2/20 0.40
SMN1; SMN2 Q16637 1/20 0.39
TOP2A P11388 1/20 0.38
ALDH1A1 P00352 1/20 0.38
MCL1 Q07820 1/20 0.37
PRSS1 P07477 1/20 0.36
CTSG P08311 1/20 0.36
CTRB1 P17538 1/20 0.36
CMA1 P23946 1/20 0.36
POLB P06746 1/20 0.36
MEN1 O00255 1/20 0.36
KMT2A Q03164 1/20 0.36
MDM4 O15151 1/20 0.35
LMNA P02545 1/20 0.35
MAPT P10636 1/20 0.35
MDM2 Q00987 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8836859 0.90 CYP3A4 (0.41) ADORA3CYP3A4CYP2D6CYP2C19NPSR1
SCHEMBL7322396 0.84 ALDH1A1 (0.45) TOP2AALDH1A1MCL1PRSS1CTSG
SCHEMBL7323307 0.82 CYP1A2 (0.39) CYP3A4CYP2C19SMN1; SMN2TOP2AALDH1A1
SCHEMBL7321950 0.77 PPARG (0.42) ALDH1A1POLBLMNAMAPT
SCHEMBL7334498 0.76 CYP1A2 (0.39) CYP3A4CYP2C19SMN1; SMN2ALDH1A1MCL1
SCHEMBL8836853 0.76 HPGD (0.46) NPSR1SMN1; SMN2ALDH1A1MEN1KMT2A
SCHEMBL7332456 0.76 HDAC8 (0.46)
SCHEMBL7326028 0.76 MAPT (0.41) NPSR1SMN1; SMN2ALDH1A1MCL1POLB
SCHEMBL7325820 0.75 HRH4 (0.43) SMN1; SMN2ALDH1A1PRSS1CTSGCTRB1
SCHEMBL7334667 0.75 ALDH1A1 (0.43) ALDH1A1POLBMEN1KMT2ALMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5674863-A BENZODIAZEPINEDIONE DERIVATIVE; FIBRINOGIN BINDING INHIBITOR GENENTECH, INC. (US) 1997-10-07 US disclosed
US-5674865-A BENZODIAZEPINEDIONE DERIVATIVE; FIBRINOGIN BINDING INHIBITOR GENENTECH, INC. (US) 1997-10-07 US disclosed
US-5663166-A ANTICOAGULANTS OF 1,4-BENZODIAZEPINE-2,5-DIONE AND 2-BENZOAZEPINE-1,4-DIONE DERIVATIVES; PREVENTS FIBRINOGEN BINDING NECESSARY FOR PLATELET AGGREGATION; SIDE EFFECT REDUCTION, E.G. EXCESSIVE BLEEDING GENENTECH, INC. (US) 1997-09-02 US disclosed
US-5565449-A PLATELET AGGREGATION INHIBITORS GENENTECH, INC. (US) 1996-10-15 US disclosed
EP-0610334-B1 NONPEPTIDYL INTEGRIN INHIBITORS HAVING SPECIFICITY FOR THE GPII B III A RECEPTOR GENENTECH INC (US) 1996-01-24 EP disclosed
US-5403836-A Anticoagulants GENENTECH, INC. (US) 1995-04-04 US disclosed
EP-0610334-A1 NONPEPTIDYL INTEGRIN INHIBITORS HAVING SPECIFICITY FOR THE GPII b?III a? RECEPTOR. GENENTECH INC (US) 1994-08-17 EP disclosed
US-5250679-A Nonpeptidyl platelet aggregation inhibitors having specificity for the GPIIb III.sub. receptor GENENTECH, INC. (US) 1993-10-05 US disclosed
WO-1993008174-A1 NONPEPTIDYL INTEGRIN INHIBITORS HAVING SPECIFICITY FOR THE GPIIbIIIa RECEPTOR GENENTECH, INC. (US) 1993-04-29 WO disclosed