SCHEMBL7324656

SCHEMBL7324656

CCOC(=O)CCN1CC(=O)N(Cc2cccc3ccccc23)c2ccc(CCCCCCNC(=O)OC(C)(C)C)cc2C1=O

nearest known ligand 0.38

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
BRD4 O60885 1/20 0.38
DRD2 P14416 4/20 0.38
TPSAB1 Q15661 1/20 0.38
TPSD1 Q9BZJ3 1/20 0.38
TPSG1 Q9NRR2 1/20 0.38
SLC2A1 P11166 1/20 0.37
NQO2 P16083 1/20 0.36
NAMPT P43490 1/20 0.35
SIGMAR1 Q99720 2/20 0.35
PDCD1 Q15116 1/20 0.34
CD274 Q9NZQ7 1/20 0.34
TLR7 Q9NYK1 1/20 0.34
EDNRA P25101 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7333068 1.00 BRD4 (0.38) BRD4DRD2TPSAB1TPSD1TPSG1
SCHEMBL7357220 0.91 TPSAB1 (0.39) BRD4DRD2TPSAB1TPSD1TPSG1
SCHEMBL7321682 0.90 TPSAB1 (0.39) BRD4DRD2TPSAB1TPSD1TPSG1
SCHEMBL8842938 0.90 TPSAB1 (0.39) BRD4DRD2TPSAB1TPSD1TPSG1
SCHEMBL7357533 0.88 TPSAB1 (0.38) BRD4DRD2TPSAB1TPSD1TPSG1
SCHEMBL7362781 0.88 TPSAB1 (0.38) BRD4DRD2TPSAB1TPSD1TPSG1
SCHEMBL7331215 0.87 TPSAB1 (0.39) BRD4DRD2TPSAB1TPSD1TPSG1
SCHEMBL7361241 0.87 TPSAB1 (0.37) BRD4DRD2TPSAB1TPSD1TPSG1
SCHEMBL7330496 0.87 TPSAB1 (0.39) BRD4DRD2TPSAB1TPSD1TPSG1
SCHEMBL7356624 0.86 TPSAB1 (0.37) BRD4DRD2TPSAB1TPSD1TPSG1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5674863-A BENZODIAZEPINEDIONE DERIVATIVE; FIBRINOGIN BINDING INHIBITOR GENENTECH, INC. (US) 1997-10-07 US disclosed
US-5674865-A BENZODIAZEPINEDIONE DERIVATIVE; FIBRINOGIN BINDING INHIBITOR GENENTECH, INC. (US) 1997-10-07 US disclosed
US-5663166-A ANTICOAGULANTS OF 1,4-BENZODIAZEPINE-2,5-DIONE AND 2-BENZOAZEPINE-1,4-DIONE DERIVATIVES; PREVENTS FIBRINOGEN BINDING NECESSARY FOR PLATELET AGGREGATION; SIDE EFFECT REDUCTION, E.G. EXCESSIVE BLEEDING GENENTECH, INC. (US) 1997-09-02 US disclosed
US-5565449-A PLATELET AGGREGATION INHIBITORS GENENTECH, INC. (US) 1996-10-15 US disclosed
EP-0610334-B1 NONPEPTIDYL INTEGRIN INHIBITORS HAVING SPECIFICITY FOR THE GPII B III A RECEPTOR GENENTECH INC (US) 1996-01-24 EP disclosed
US-5403836-A Anticoagulants GENENTECH, INC. (US) 1995-04-04 US disclosed
EP-0610334-A1 NONPEPTIDYL INTEGRIN INHIBITORS HAVING SPECIFICITY FOR THE GPII b?III a? RECEPTOR. GENENTECH INC (US) 1994-08-17 EP disclosed
US-5250679-A Nonpeptidyl platelet aggregation inhibitors having specificity for the GPIIb III.sub. receptor GENENTECH, INC. (US) 1993-10-05 US disclosed
WO-1993008174-A1 NONPEPTIDYL INTEGRIN INHIBITORS HAVING SPECIFICITY FOR THE GPIIbIIIa RECEPTOR GENENTECH, INC. (US) 1993-04-29 WO disclosed