Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | REN | P00797 | 15/20 | 0.48 |
| ▸ | CTSS | P25774 | 2/20 | 0.46 |
| ▸ | CTSL | P07711 | 1/20 | 0.46 |
| ▸ | CTSB | P07858 | 1/20 | 0.46 |
| ▸ | CTSK | P43235 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7324676 | 1.00 | REN (0.48) | RENCTSSCTSLCTSBCTSK | |
| SCHEMBL7316242 | 0.94 | REN (0.53) | REN | |
| SCHEMBL7315458 | 0.94 | REN (0.53) | REN | |
| SCHEMBL7317387 | 0.94 | REN (0.53) | REN | |
| SCHEMBL7314662 | 0.90 | REN (0.55) | REN | |
| SCHEMBL7309924 | 0.90 | REN (0.55) | REN | |
| Acetic Acid SCHEMBL7326759 | 0.89 | REN (0.54) | REN | |
| SCHEMBL23598225 | 0.83 | ACE (0.57) | RENCTSSCTSLCTSBCTSK | |
| SCHEMBL7300127 | 0.83 | ACE (0.57) | RENCTSSCTSLCTSBCTSK | |
| SCHEMBL10522069 | 0.83 | ACE (0.57) | RENCTSSCTSLCTSBCTSK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0231919-B1 | N-HETEROCYCLIC ALCOHOL RENIN INHIBITORS | E.R. Squibb & Sons, Inc. (US) | 1993-01-20 | — | — | EP | disclosed |
| EP-0231919-A2 | N-Heterocyclic alcohol renin inhibitors | E.R. Squibb & Sons, Inc. (US) | 1987-08-12 | — | — | EP | disclosed |