Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.56 |
| ▸ | MEN1 | O00255 | 2/20 | 0.56 |
| ▸ | SLC7A5 | Q01650 | 2/20 | 0.49 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.47 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.47 |
| ▸ | ABL1 | P00519 | 1/20 | 0.46 |
| ▸ | RIN1 | Q13671 | 1/20 | 0.46 |
| ▸ | GPR119 | Q8TDV5 | 3/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | TPH1 | P17752 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | CNR2 | P34972 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | SETD7 | Q8WTS6 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7387226 | 1.00 | KMT2A (0.56) | KMT2AMEN1SLC7A5EPHX2HDAC4 | |
| SCHEMBL8250652 | 0.85 | MEN1 (0.61) | KMT2AMEN1EPHX2HDAC4ABL1 | |
| SCHEMBL21690101 | 0.82 | ACACB (0.57) | KMT2AMEN1SLC7A5SMN1; SMN2CYP2C19 | |
| SCHEMBL8427895 | 0.81 | KMT2A (0.65) | KMT2AMEN1EPHX2HDAC4ABL1 | |
| SCHEMBL2251044 | 0.80 | KMT2A (0.67) | KMT2AMEN1EPHX2HDAC4ABL1 | |
| SCHEMBL3900270 | 0.79 | KMT2A (0.70) | KMT2AMEN1EPHX2HDAC4ABL1 | |
| SCHEMBL6345217 | 0.79 | HDAC8 (0.56) | GPR119 | |
| SCHEMBL14393707 | 0.79 | KMT2A (0.62) | KMT2AMEN1EPHX2HDAC4ABL1 | |
| SCHEMBL7130405 | 0.78 | HDAC8 (0.54) | KMT2AMEN1SLC7A5GPR119SMN1; SMN2 | |
| SCHEMBL2617199 | 0.78 | SLC7A5 (0.71) | KMT2AMEN1SLC7A5SMN1; SMN2TPH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6420418-B1 | INHIBITION AND PREVENTION OF LEUKOCYTE ADHESION; USED TO TREAT ADHESION-MEDIATED DISEASES SUCH AS ASTHMA, ALLERGIC RHINITIS, MULTIPLE SCLEROSIS; ATHEROSCLEROSIS, AND INFLAMMATORY BOWEL DISEASE | MERCK & CO., INC. | 2002-07-16 | — | — | US | disclosed |
| US-6403584-B1 | CONJUNCTIVITIS, ALLERGIC RHINITIS, ALZHEIMER'S DISEASE, ASTHMA, ATHEROSCLEROSIS, AUTOLOGOUS BONE MARROW TRANSPLANTATION, ANTIINFLAMMATORY, ETC | MERCK & CO., INC. | 2002-06-11 | — | — | US | disclosed |
| WO-2001012183-A1 | HETEROCYCLE AMIDES AS CELL ADHESION INHIBITORS | MERCK & CO., INC. (US) | 2001-02-22 | — | — | WO | disclosed |