Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.54 |
| ▸ | MEN1 | O00255 | 4/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.48 |
| ▸ | HRH2 | P25021 | 1/20 | 0.48 |
| ▸ | HRH1 | P35367 | 1/20 | 0.48 |
| ▸ | DPP4 | P27487 | 2/20 | 0.47 |
| ▸ | KDM1A | O60341 | 1/20 | 0.46 |
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.46 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | ATM | Q13315 | 1/20 | 0.44 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | SMYD3 | Q9H7B4 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6345217 | 0.89 | HDAC8 (0.56) | HDAC8OPRD1DPP4GPR119 | |
| SCHEMBL3142935 | 0.86 | MEN1 (0.51) | MEN1KMT2APOLBKDM1AGPR119 | |
| SCHEMBL316881 | 0.80 | LMNA (0.50) | MEN1KMT2APOLBOPRD1DPP4 | |
| SCHEMBL316880 | 0.80 | LMNA (0.50) | MEN1KMT2APOLBOPRD1DPP4 | |
| SCHEMBL3360247 | 0.80 | ACKR3 (0.49) | HRH2HRH1HTTSMN1; SMN2 | |
| SCHEMBL3360242 | 0.80 | ACKR3 (0.49) | HRH2HRH1HTTSMN1; SMN2 | |
| SCHEMBL14390395 | 0.80 | HDAC8 (0.67) | HDAC8OPRD1HRH2HRH1DPP4 | |
| SCHEMBL7324837 | 0.78 | KMT2A (0.56) | MEN1KMT2ASLC7A5GPR119HTT | |
| SCHEMBL7387226 | 0.78 | KMT2A (0.56) | MEN1KMT2ASLC7A5GPR119HTT | |
| SCHEMBL4156092 | 0.78 | VEGFA (0.58) | MEN1KMT2AKDM1AHTTESR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2003047515-A2 | P2X7 RECEPTOR ANTAGONISTS | THE GOVERNMENT OF THE UNITED STATES OF AMERICA, REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 2003-06-12 | — | — | WO | disclosed |