Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACE | P12821 | 9/20 | 0.58 |
| ▸ | MME | P08473 | 1/20 | 0.53 |
| ▸ | SRC | P12931 | 2/20 | 0.52 |
| ▸ | TPSAB1 | Q15661 | 2/20 | 0.49 |
| ▸ | TPSD1 | Q9BZJ3 | 2/20 | 0.49 |
| ▸ | TPSG1 | Q9NRR2 | 2/20 | 0.49 |
| ▸ | F2 | P00734 | 2/20 | 0.42 |
| ▸ | F10 | P00742 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7325000 | 1.00 | ACE (0.58) | ACEMMESRCTPSAB1TPSD1 | |
| SCHEMBL7321699 | 0.97 | ACE (0.58) | ACEMMESRCTPSAB1TPSD1 | |
| SCHEMBL7321687 | 0.97 | ACE (0.58) | ACEMMESRCTPSAB1TPSD1 | |
| SCHEMBL7322575 | 0.85 | ACE (0.55) | ACEMMESRCTPSAB1TPSD1 | |
| SCHEMBL7322584 | 0.85 | ACE (0.55) | ACEMMESRCTPSAB1TPSD1 | |
| SCHEMBL7427924 | 0.84 | ACE (0.42) | ACESRC | |
| SCHEMBL7423479 | 0.84 | SRC (0.53) | ACESRC | |
| SCHEMBL7330364 | 0.82 | ACE (0.55) | ACEMMESRCTPSAB1TPSD1 | |
| SCHEMBL7330368 | 0.82 | ACE (0.55) | ACEMMESRCTPSAB1TPSD1 | |
| SCHEMBL7333437 | 0.81 | ACE (0.43) | ACEMMETPSAB1TPSD1TPSG1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4533661-A | Certain 3-phosphinyl-amino-2-oxo-1H-azepine-1-acetic acid derivatives having anti-hypertensive activity | E. R. SQUIBB & SONS, INC. (US) | 1985-08-06 | — | — | US | claimed |
| US-4598071-A | ANGIOTENSIN INHIBITORS/ | E. R. SQUIBB & SONS, INC. (US) | 1986-07-01 | — | — | US | disclosed |
| US-4567167-A | INHIBITOR OF ANGIOTENDIN CONVERTING ENZYME | E. R. SQUIBB & SONS, INC. (US) | 1986-01-28 | — | — | US | disclosed |
| US-4533661-A | Certain 3-phosphinyl-amino-2-oxo-1H-azepine-1-acetic acid derivatives having anti-hypertensive activity | E. R. SQUIBB & SONS, INC. (US) | 1985-08-06 | — | — | US | disclosed |