Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Dexamethasone. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR3C1 known ✓ | P04150 | 7/20 | 0.93 |
| ▸ | HIF1A | Q16665 | 9/20 | 0.93 |
| ▸ | CYP3A4 | P08684 | 7/20 | 0.93 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.93 |
| ▸ | NFKB1 | P19838 | 3/20 | 0.93 |
| ▸ | PGR | P06401 | 3/20 | 0.93 |
| ▸ | TSHR | P16473 | 2/20 | 0.93 |
| ▸ | AR | P10275 | 2/20 | 0.93 |
| ▸ | PMP22 | Q01453 | 2/20 | 0.93 |
| ▸ | MEN1 | O00255 | 1/20 | 0.93 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.93 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.93 |
| ▸ | APEX1 | P27695 | 1/20 | 0.93 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.93 |
| ▸ | IKBKB | O14920 | 1/20 | 0.93 |
| ▸ | CHUK | O15111 | 1/20 | 0.93 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.93 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.93 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.93 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.93 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Betamethasone SCHEMBL7426 | 1.00 | HIF1A (0.93) | HIF1ACYP3A4NR3C1HSD17B10NFKB1 | |
| Dexamethasone SCHEMBL4973562 | 1.00 | HIF1A (0.93) | HIF1ACYP3A4NR3C1HSD17B10NFKB1 | |
| Dexamethasone SCHEMBL1561578 | 1.00 | HIF1A (0.93) | HIF1ACYP3A4NR3C1HSD17B10NFKB1 | |
| Betamethasone SCHEMBL5501682 | 1.00 | HIF1A (0.93) | HIF1ACYP3A4NR3C1HSD17B10NFKB1 | |
| Betamethasone SCHEMBL27476350 | 1.00 | HIF1A (0.93) | HIF1ACYP3A4NR3C1HSD17B10NFKB1 | |
| Betamethasone SCHEMBL8529637 | 1.00 | HIF1A (0.93) | HIF1ACYP3A4NR3C1HSD17B10NFKB1 | |
| Betamethasone SCHEMBL28777880 | 0.99 | HIF1A (0.92) | HIF1ACYP3A4NR3C1HSD17B10NFKB1 | |
| Betamethasone SCHEMBL1479323 | 0.99 | HIF1A (0.92) | HIF1ACYP3A4NR3C1HSD17B10NFKB1 | |
| Betamethasone SCHEMBL2807697 | 0.99 | HIF1A (0.92) | HIF1ACYP3A4NR3C1HSD17B10NFKB1 | |
| Dexamethasone SCHEMBL2808007 | 0.99 | HIF1A (0.92) | HIF1ACYP3A4NR3C1HSD17B10NFKB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 4296 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-121490062-B | Dexamethasone-containing composition and application thereof in preparation of medicament for treating retinopathy | 上饶爱尔眼科医院有限公司 | 2026-05-15 | — | — | CN | claimed |
| US-20260108657-A1 | PHARMACEUTICAL COMPOSITIONS FOR TREATING OSTEOARTHRITIS | INSIGNIA PHARMACEUTICALS, LLC (US) | 2026-04-23 | — | — | US | claimed |
| US-12551148-B2 | Systems and methods for compensating for agent elution | MEDTRONIC MINIMED, INC. (US) | 2026-02-17 | — | — | US | claimed |
| US-20260021113-A1 | INTRAVITREAL CORTICOSTEROID EXTENDED RELEASE IMPLANT AND METHODS OF USE | EYEDEA BIO LLC (US) | 2026-01-22 | — | — | US | claimed |
| US-12491289-B2 | Pharmaceutical compositions for treating osteoarthritis | INSIGNIA PHARMACEUTICALS, LLC (US) | 2025-12-09 | — | — | US | claimed |
| EP-4654956-A1 | PHARMACEUTICAL COMPOSITIONS FOR TREATING OSTEOARTHRITIS | Insignia Pharmaceuticals, LLC (US) | 2025-12-03 | — | — | EP | claimed |
| US-12433900-B2 | Intravitreal corticosteroid extended release implant and methods of use | EYEDEA BIO, LLC (US) | 2025-10-07 | — | — | US | claimed |
| US-20250295608-A1 | PHARMACEUTICAL COMPOSITIONS AND METHODS FOR TREATING OSTEOARTHRITIS | INSIGNIA PHARMACEUTICALS, LLC (US) | 2025-09-25 | — | — | US | claimed |
| US-20250288599-A1 | PHARMACEUTICAL COMPOSITIONS AND METHODS FOR TREATING OSTEOARTHRITIS | INSIGNIA PHARMACEUTICALS, LLC (US) | 2025-09-18 | — | — | US | claimed |
| US-20250275916-A1 | MEDICATED EYELID CLEANSING COMPOSITIONS | OCUSOFT, INC. | 2025-09-04 | — | — | US | claimed |
| EP-0622090-A1 | Sintered electrode on a substrate | MEDTRONIC, INC. (US) | 1994-11-02 | — | — | EP | claimed |
| US-5282844-A | High impedance, low polarization, low threshold miniature steriod eluting pacing lead electrodes | MEDTRONIC, INC. (US) | 1994-02-01 | — | — | US | claimed |
| US-5232441-A | Method of treating schistosomal infestations by iontophoresis | PHYSION S.R.L. (IT) | 1993-08-03 | — | — | US | claimed |
| CN-1073859-A | Regulate the compositions of wrinkle of skin and/or atrophoderma | RICHARDSON VICKS INC (US) | 1993-07-07 | — | — | CN | claimed |
| EP-0538368-A1 | MINIATURE STEROID ELUTING PACING LEAD ELECTRODE | MEDTRONIC, INC. (US) | 1993-04-28 | — | — | EP | claimed |
| WO-1991019533-A1 | MINIATURE STEROID ELUTING PACING LEAD ELECTRODE | MEDTRONIC, INC. (US) | 1991-12-26 | — | — | WO | claimed |
| US-4506680-A | Drug dispensing body implantable lead | MEDTRONIC, INC. (US) | 1985-03-26 | — | — | US | claimed |
| US-4346709-A | Drug delivery devices comprising erodible polymer and erosion rate modifier | ALZA CORPORATION (US) | 1982-08-31 | — | — | US | claimed |
| EP-0056420-A1 | Ophthalmic gel | SCHERING CORPORATION (US) | 1982-07-28 | — | — | EP | claimed |
| US-4255415-A | COMPRISING A MEDICAMENT, A VINYL ACETATE-VINYL ALCOHOL COPOLYMER, AN ALKALI OR ALKALINE BORATE, AND STERILE WATER; TOPICAL | SCHERING CORPORATION (US) | 1981-03-10 | — | — | US | claimed |