Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Betamethasone. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR3C1 known ✓ | P04150 | 7/20 | 0.93 |
| ▸ | HIF1A | Q16665 | 9/20 | 0.93 |
| ▸ | CYP3A4 | P08684 | 7/20 | 0.93 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.93 |
| ▸ | NFKB1 | P19838 | 3/20 | 0.93 |
| ▸ | PGR | P06401 | 3/20 | 0.93 |
| ▸ | TSHR | P16473 | 2/20 | 0.93 |
| ▸ | AR | P10275 | 2/20 | 0.93 |
| ▸ | PMP22 | Q01453 | 2/20 | 0.93 |
| ▸ | MEN1 | O00255 | 1/20 | 0.93 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.93 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.93 |
| ▸ | APEX1 | P27695 | 1/20 | 0.93 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.93 |
| ▸ | IKBKB | O14920 | 1/20 | 0.93 |
| ▸ | CHUK | O15111 | 1/20 | 0.93 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.93 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.93 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.93 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.93 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Dexamethasone SCHEMBL4973562 | 1.00 | HIF1A (0.93) | HIF1ACYP3A4NR3C1HSD17B10NFKB1 | |
| Dexamethasone SCHEMBL1561578 | 1.00 | HIF1A (0.93) | HIF1ACYP3A4NR3C1HSD17B10NFKB1 | |
| Dexamethasone SCHEMBL73250 | 1.00 | HIF1A (0.93) | HIF1ACYP3A4NR3C1HSD17B10NFKB1 | |
| Betamethasone SCHEMBL5501682 | 1.00 | HIF1A (0.93) | HIF1ACYP3A4NR3C1HSD17B10NFKB1 | |
| Betamethasone SCHEMBL27476350 | 1.00 | HIF1A (0.93) | HIF1ACYP3A4NR3C1HSD17B10NFKB1 | |
| Betamethasone SCHEMBL8529637 | 1.00 | HIF1A (0.93) | HIF1ACYP3A4NR3C1HSD17B10NFKB1 | |
| Betamethasone SCHEMBL28777880 | 0.99 | HIF1A (0.92) | HIF1ACYP3A4NR3C1HSD17B10NFKB1 | |
| Betamethasone SCHEMBL1479323 | 0.99 | HIF1A (0.92) | HIF1ACYP3A4NR3C1HSD17B10NFKB1 | |
| Betamethasone SCHEMBL2807697 | 0.99 | HIF1A (0.92) | HIF1ACYP3A4NR3C1HSD17B10NFKB1 | |
| Dexamethasone SCHEMBL2808007 | 0.99 | HIF1A (0.92) | HIF1ACYP3A4NR3C1HSD17B10NFKB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1024 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20250255826-A1 | PROCESS FOR THE PREPARATION OF ERYTHROCYTES LOADED WITH ONE OR MORE SUBSTANCES OF PHARMACEUTICAL INTEREST AND SO OBTAINED ERYTHROCYTES | QUINCE THERAPEUTICS, INC. | 2025-08-14 | — | — | US | claimed |
| CN-119780280-A | Method for measuring betamethasone sodium phosphate injection disodium edetate by liquid chromatography | 辰欣药业股份有限公司 | 2025-04-08 | — | — | CN | claimed |
| US-20250025426-A1 | SYNERGISTIC TRANSPORT OF LIPOPHILIC AND HYDROPHILIC ACTIVE SUBSTANCES IN NANOPARTICLES | Karlsruher Institut für Technologie (DE) | 2025-01-23 | — | — | US | claimed |
| US-12145951-B2 | Inorganic-organic hybrid compounds including organic platinum-containing anions, for use in medicine | KARLSRUHER INSTITUT FUR TECHNOLOGIE (DE) | 2024-11-19 | — | — | US | claimed |
| EP-4444275-A1 | SYNERGISTIC TRANSPORT OF LIPOPHILIC AND HYDROPHILIC ACTIVE SUBSTANCES IN NANOPARTICLES | Karlsruher Institut für Technologie (DE) | 2024-10-16 | — | — | EP | claimed |
| EP-4420656-A1 | PHARMACEUTICAL COMPOSITION AND METHOD FOR PRODUCING SAME | Sunsho Pharmaceutical Co., Ltd. (JP) | 2024-08-28 | — | — | EP | claimed |
| CN-114224821-B | Coated contact lenses comprising an osmotic pressure-based enhanced drug posterior ocular delivery system and methods of making the same | 沈阳药科大学 | 2024-08-06 | — | — | CN | claimed |
| US-20240189479-A1 | Cardiovascular Prostheses | CORVIVO CARDIOVASCULAR, INC. | 2024-06-13 | — | — | US | claimed |
| CN-110251827-B | Corticosteroid children phimosis treatment sleeve and use method thereof | 广州医科大学附属清远医院(清远市人民医院) | 2024-05-10 | — | — | CN | claimed |
| CN-117159443-B | In-situ supermolecule gel microneedle patch and preparation method and application thereof | 暨南大学 | 2024-04-19 | — | — | CN | claimed |
| CN-1764442-A | Intravenous nanoparticles for targenting drug delivery and sustained drug release | LTT BIO PHARMA CO LTD (JP) | 2006-04-26 | — | — | CN | claimed |
| EP-1594482-A1 | INTRAVENOUS NANOPARTICLES FOR TARGETING DRUG DELIVERY AND SUSTAINED DRUG RELEASE | LTT Bio-Pharma Co., Ltd. (JP) | 2005-11-16 | — | — | EP | claimed |
| WO-2004084871-A1 | INTRAVENOUS NANOPARTICLES FOR TARGENTING DRUG DELIVERY AND SUSTAINED DRUG RELEASE | LTT BIO-PHARMA CO., LTD. (JP) | 2004-10-07 | — | — | WO | claimed |
| EP-0622072-B1 | Stable aqueous dispersions containing liposomes | WAKAMOTO PHARMA CO LTD (JP) | 2000-09-06 | — | — | EP | claimed |
| CN-1048393-C | Aqueous drug composition having property of reversible thermosetting gelation | WAKAMOTO PHARMA CO LTD (JP) | 2000-01-19 | — | — | CN | claimed |
| US-5569464-A | ENCAPSULATING DRUGS | WAKAMOTO PHARMACEUTICAL CO., LTD. (JP) | 1996-10-29 | — | — | US | claimed |
| CN-1097593-A | Aqueous drug composition having property of reversible thermosetting gelation | WAKAMOTO PHARMA CO LTD (JP) | 1995-01-25 | — | — | CN | claimed |
| EP-0622072-A2 | Stable aqueous dispersions containing liposomes | Wakamoto Pharmaceutical Co., Ltd. (JP) | 1994-11-02 | — | — | EP | claimed |
| EP-0056420-A1 | Ophthalmic gel | SCHERING CORPORATION (US) | 1982-07-28 | — | — | EP | claimed |
| US-4255415-A | COMPRISING A MEDICAMENT, A VINYL ACETATE-VINYL ALCOHOL COPOLYMER, AN ALKALI OR ALKALINE BORATE, AND STERILE WATER; TOPICAL | SCHERING CORPORATION (US) | 1981-03-10 | — | — | US | claimed |