SCHEMBL7325201

SCHEMBL7325201

N[C@@H](COC1(c2ccc(Cl)cc2)c2ccccc2-c2ccccc21)C(=O)O

nearest known ligand 0.59

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
CYP1A2 P05177 1/20 0.59
CYP2C19 P33261 1/20 0.59
HIF1A Q16665 1/20 0.59
KIF11 P52732 12/20 0.49
SLC1A5 Q15758 2/20 0.39
MDM2 Q00987 2/20 0.38
CYP2D6 P10635 2/20 0.38
CYP3A4 P08684 1/20 0.38
TP53 P04637 1/20 0.37
SLC6A1 P30531 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7314907 0.91 KIF11 (0.55) CYP1A2CYP2C19HIF1AKIF11SLC1A5
SCHEMBL7323114 0.91 KIF11 (0.55) CYP1A2CYP2C19HIF1AKIF11SLC1A5
SCHEMBL7326122 0.87 KIF11 (0.59) CYP1A2CYP2C19HIF1AKIF11SLC1A5
SCHEMBL7318407 0.87 KIF11 (0.59) CYP1A2CYP2C19HIF1AKIF11SLC1A5
SCHEMBL7314852 0.86 CYP1A2 (0.46) CYP1A2CYP2C19HIF1AKIF11SLC1A5
SCHEMBL7313597 0.81 KIF11 (0.49) CYP1A2CYP2C19HIF1AKIF11SLC1A5
SCHEMBL7326447 0.79 KIF11 (0.47) CYP1A2CYP2C19HIF1AKIF11SLC1A5
SCHEMBL7322800 0.78 KIF11 (0.45) CYP1A2CYP2C19HIF1AKIF11SLC1A5
SCHEMBL7318773 0.78 KIF11 (0.44) CYP1A2CYP2C19HIF1AKIF11MDM2
SCHEMBL7324156 0.77 KIF11 (0.50) CYP1A2CYP2C19HIF1AKIF11SLC1A5

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-1999041227-A1 TRICYCLIC COMPOUNDS AS GLYCINE TRANSPORT INHIBITORS ALLELIX NEUROSCIENCE, INC. (US) 1999-08-19 WO claimed
US-6162824-A NERVOUS SYSTEM DISORDERS; PSYCHOLOGICAL DISORDERS ALLELIX NEUROSCIENCE INC. 2000-12-19 US disclosed
WO-1999041227-A1 TRICYCLIC COMPOUNDS AS GLYCINE TRANSPORT INHIBITORS ALLELIX NEUROSCIENCE, INC. (US) 1999-08-19 WO disclosed