Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAM17 | P78536 | 20/20 | 0.79 |
| ▸ | MMP13 | P45452 | 8/20 | 0.63 |
| ▸ | MMP9 | P14780 | 4/20 | 0.60 |
| ▸ | MMP1 | P03956 | 4/20 | 0.53 |
| ▸ | MMP2 | P08253 | 2/20 | 0.52 |
| ▸ | MMP14 | P50281 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3938344 | 0.89 | ADAM17 (1.00) | ADAM17MMP13MMP9MMP1MMP2 | |
| SCHEMBL6657607 | 0.87 | ADAM17 (0.79) | ADAM17MMP13MMP9MMP1MMP2 | |
| SCHEMBL6655838 | 0.87 | ADAM17 (0.79) | ADAM17MMP13MMP9MMP1 | |
| SCHEMBL6782213 | 0.84 | ADAM17 (0.82) | ADAM17MMP13MMP9MMP1MMP2 | |
| SCHEMBL6786664 | 0.81 | ADAM17 (0.83) | ADAM17MMP13MMP9MMP1MMP2 | |
| SCHEMBL6659308 | 0.80 | ADAM17 (0.64) | ADAM17MMP13MMP9MMP1MMP2 | |
| SCHEMBL6656672 | 0.80 | ADAM17 (0.60) | ADAM17MMP13MMP9MMP1MMP2 | |
| SCHEMBL6785659 | 0.78 | ADAM17 (0.73) | ADAM17MMP13MMP9MMP1 | |
| SCHEMBL6659884 | 0.77 | ADAM17 (1.00) | ADAM17MMP13MMP9MMP1MMP14 | |
| SCHEMBL3949526 | 0.76 | ADAM17 (1.00) | ADAM17MMP13MMP9MMP1MMP14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1230243-A1 | POYCYLOALKYLPURINES AS ADENOSINE RECEPTOR ANTAGONISTS | BIOGEN, INC. (US) | 2002-08-14 | — | — | EP | disclosed |
| US-6340691-B1 | TREATMENT OF ARTHRITIS, TUMOR METASTASIS, TISSUE ULCERATION, ABNORMAL WOUND HEALING, PERIODONTAL DISEASE, BONE DISEASE, DIABETES (INSULIN RESISTANCE) AND HIV INFECTION | AMERICAN CYANAMID COMPANY | 2002-01-22 | — | — | US | disclosed |
| EP-1147080-A1 | ALKYNYL CONTAINING HYDROXAMIC ACID COMPOUNDS AS TACE INHIBITORS | American Cyanamid Company (US) | 2001-10-24 | — | — | EP | disclosed |
| WO-2001034610-A1 | POLYCYCLOALKYLPURINES AS ADENOSINE RECEPTOR ANTAGONISTS | BIOGEN, INC. (US) | 2001-05-17 | — | — | WO | disclosed |
| WO-2000044713-A1 | ALKYNYL CONTAINING HYDROXAMIC ACID COMPOUNDS AS TACE INHIBITORS | AMERICAN CYANAMID COMPANY (US) | 2000-08-03 | — | — | WO | disclosed |