Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.38 |
| ▸ | THRB | P10828 | 2/20 | 0.37 |
| ▸ | THRA | P10827 | 1/20 | 0.36 |
| ▸ | CNR2 | P34972 | 1/20 | 0.36 |
| ▸ | MAOA | P21397 | 1/20 | 0.36 |
| ▸ | MAOB | P27338 | 1/20 | 0.36 |
| ▸ | SOAT1 | P35610 | 8/20 | 0.35 |
| ▸ | USP2 | O75604 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | AR | P10275 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28372080 | 1.00 | TP53 (0.41) | TP53TDP1PTGS2THRBTHRA | |
| SCHEMBL11443820 | 0.84 | THRB (0.40) | TDP1PTGS2THRBTHRACNR2 | |
| SCHEMBL11443833 | 0.84 | THRB (0.40) | TDP1PTGS2THRBTHRACNR2 | |
| SCHEMBL7325426 | 0.84 | SOAT1 (0.38) | THRBTHRACNR2MAOAMAOB | |
| SCHEMBL11429530 | 0.84 | THRB (0.40) | TDP1PTGS2THRBTHRACNR2 | |
| SCHEMBL11431899 | 0.84 | THRB (0.40) | TDP1PTGS2THRBTHRACNR2 | |
| SCHEMBL11431849 | 0.84 | THRB (0.40) | TDP1PTGS2THRBTHRACNR2 | |
| SCHEMBL10497865 | 0.84 | THRB (0.40) | TDP1PTGS2THRBTHRACNR2 | |
| SCHEMBL11430039 | 0.84 | THRB (0.40) | TDP1PTGS2THRBTHRACNR2 | |
| SCHEMBL25832110 | 0.80 | THRB (0.46) | PTGS2THRBTHRAMAOAMAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4845100-A | WITH HYPOTENSIVE AND ANTIINFLAMMATORY ACTIVITY | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1989-07-04 | — | — | US | disclosed |
| EP-0202760-A2 | Carbostyril derivatives and salts thereof, processes for preparing the same and cardiotonic composition containing the same | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1986-11-26 | — | — | EP | disclosed |